Ihe Na-emetụta HPMC

Otutu nke hydropylthylthyl methylcellose (hpdropyythm methylcelllose) Ihe ndị a dị ezigbo mkpa na ntinye nke HPMC na arụmọrụ ya na ọgwụ, nri, owuwu na ọrụ ndị ọzọ.

1. Na akụrụngwa anụ ahụ

1.1 molecular ibu
Ibu molecular nke HPMC bụ ihe dị mkpa na-emetụta onye so ya. N'ozuzu, ibu buolecular ibu, ji nwayọ nwayọ. Nke a bụ n'ihi na oke molecula na-arụpụta nnukwu mkpụrụ, nke na-abawanye mkpọchi na mmekọrịta dị n'etiti ụmụ irighiri ihe, si otú a na-agbada usoro mgbasa. Kama nke ahụ, HPMC nwere obere molecular na-agbaze ngwa ngwa, mana ihe ngwọta ya nwere ike ịdị ala, na-eme ya ekwesighi maka ụfọdụ ngwa.

1.2 ogo nke nnọchi
Oru nke nbanye nke HPMC (ya bụ ogo nke dochie methoxy na hydroxypropoxy otu) na-emetụtakwa onye so ya. HPMC na ogo dị elu nke Methoxy na Hydroxypropoxy Nchichi na-enwekarị nkwado na mmiri n'ihi na ndị a machibidoro nwere ike ịbawanye hydrophility nke molietion ma kwalite hydrophility. Agbanyeghị, nnọchi anya ngafe pụrụ iduga na mbelata nke HPMC na ụfọdụ ndokwa ụfọdụ, nke metụtara polaraty nke mmekọrịta na akwara.

1.3 nha
Urughuru nke HPMC nwere mmetụta na-emetụta ya na ọnụego ya. Obere urughuru size, mpaghara elu a kapịrị ọnụ n'otu oge, na mpaghara ahụ kpughere mgbatị ahụ na-abawanye ụba, si otú ahụ na-eme ka usoro dịkwuo elu. Ya mere, HPMC na ezigbo ntụ ntụ na-abụkarị ngwa ngwa griiz.

2. Ọnọdụ ihe mgbu

Ụdị 2.1 ụdị
Nkwelite nke HPMC dịgasị iche iche na mgbazi dị iche iche. HPMC nwere ezigbo ngelite na mmiri, karịsịa mmiri ọkụ. Ihe mgbaaka na-abụghị nke a dị ka ethanol, propylene glycol, ethylene glycol, wdg. Enwere ike igbari hpmc, mana ọsọ ọsọ na sosibility na-adịkarị ala karịa mmiri. N'ime mmakọta na-edozi ahụ, solublity na-adabere na oke nke ihe ndị mejupụtara ya na mmekọrịta ha na HPMC.

2.2 okpomọkụ
Ọnọdụ okpomọkụ nwere mmetụta dị ukwuu na solublity nke HPMC. N'ikwu okwu, HPMC agbasasịwo nwayọọ na mmiri oyi, mana dị ka ọnọdụ okpomọkụ na-abawanye, ọnụego ya na-abawanye na mmiri 40-50 Celsius. Agbanyeghị, na oke okpomọkụ (ọ na-abụkarị 70 Celsius C), HPMC nwere ike ibute ma ọ bụ mejupụta gel, nke metụtara mgbanwe na akụrụngwa ya na akụrụngwa ya.

2.3 Uru
Mgbalị nke HPMC dịtụ mma n'okpuru ọnọdụ pọpụ dị iche iche, mana acdancedị plọ dị egwu (dịka acid siri ike (dịka alkali ma ọ bụ alkali) nwere ike imetụta ya na ịkwado ya na nkwụsi ike. HPMC n'ozuzu nwere ikike kachasị mma n'okpuru ịnọpụ iche ma ọ bụ ọnọdụ nke na-anọpụ iche.

3. Ihe mpụga gburugburu ebe obibi

3.1 Ọnọdụ na-akpali akpali
Ọsọ na-akpali akpali na usoro nwere mmetụta dị ukwuu na ọsọ ọsọ nke HPMC. Akpalite kwesịrị ekwesị nwere ike ịkwalite kọntaktị n'etiti HPMC na ihe mgbaasị iji zere ibipụta clumps, si otú ahụ na-eme ka usoro a na-emekọ ihe. Na-akpali akpali ngwa ngwa nwere ike ime ka egosipụta n'ụdị, na-emetụta ịdị n'otu nke ihe ngwọta.

3.2 ihe mgbakwunye
Ihe mgbakwunye ndị ọzọ na ngwọta ahụ, dị ka nnu, Electrolytes, Sustocts, wdg, ga-emetụta mbọ nke HPMC. Dịka ọmụmaatụ, nnu ụfọdụ nwere ike ịkwalite mgbasa nke HPMC, ebe nnukwu elektrọl nwere ike ibute ọdịda ma ọ bụ mgbanwe mgbanwe nke HPMC. Ihe mgbakwunye Surfa nwere ike imeziwanye ndọlite ​​nke Hpmc na ụfọdụ mmebe nke ndị na-adịghị mma ma bulie arụmọrụ nke ihe ngwọta.

4. Mkparịta ụka Ngwa

4.1 Recorrylọ ọrụ ọgwụ
N'ime ụlọ ọrụ ọgwụ, a na-ejikarị HPMC mee ihe dị ka ihe na-eme ka ọ bụrụ nke na-akwado ya - na-akwado ya na-akwado ya, yana onye na-eso ya na-emetụta ọnụego ntọhapụ na bioapality nke ọgwụ. Ya mere, na-achịkwa oke molecular, ogo ọnọdụ nbanye na mgbasa nke HPMC dị oke mkpa maka nkwadebe ọgwụ nke ọma na nke kwụsiri ike.

4.2 ụlọ ọrụ nri nri
Na ụlọ ọrụ nri, a na-eji HPMC mee ihe dị ka nke ukwu, mmachi na emififier. Ihe sonyere ya na-ekpebi mgbasa ozi ya, udidi na iguzosi ike na nri. Site na idozi ọnọdụ a na-apụ apụ, enwere ike ịleta HPMC nri.

4.3 ụlọ ọrụ owuwu
N'ime ụlọ ọrụ, a na-eji HPMC mee ihe dị ka onye na-ejide mmiri, Perbener na ihe mgbochi, yana sosbesọ ya na-emetụta usoro owuwu na ngwa agha nke ngwa agha, mkpuchi na ngwaahịa ndị ọzọ. Na-agbanwe ọnọdụ ọnọdụ na usoro ngwa nke HPMC nwere ike ime ka nsonaazụ ya na ịdịte aka nke ihe ahụ.

Ngwongwo na ihe anụ ahụ na-emetụta ndị dị ka oke molecular, ogo nke ihe mgbakwasị, yana oke ihe na-adịghị mma, oke okpomọkụ, na mpụga gburugburu ebe obibi. N'ime ngwa dị irè, solubality arụ ọrụ nke Hpmc nwere ike ebulite n'ụzọ dị mma site na iji ahọpụta ihe ndị a dị ka mkpa na gburugburu. Echiche miri emi banyere ihe ndị a ga - enyere aka melite nsonaazụ ngwa nke HPMC na ụlọ ọrụ dị iche iche ma nye nkwado maka teknụzụ na teknụzụ metụtara.