Hydroxypyl Methylcellose (HPMC) bụ usoro ihe omimi Cellulose n'ọtụtụ ụlọ, ọgwụ na ihe ịchọ mma. Nleta ọhụụ nke HPMC bụ otu n'ime ihe ngosi arụmọrụ ya n'ihi na ọ na-emetụta ihe na-agbanwe agbanwe, Njirimara Njirimara, Njirimara GEL na njirimara ndị ọzọ. Ya mere, ịghọta ihe ndị metụtara viscosity nke HPMC dị oke mkpa maka ngwa ya na imewe ngwaahịa na mpaghara dị iche iche.
1. Mmetụta nke oke molecular
Ibu akwara nke HPMC nwere mmetụta dị ukwuu na viscosity. Nnukwu molecular ibu, onye dị elu na viscosity nke ihe ngwọta. Nke a bụ n'ihi na HPMC nwere nnukwu molecular ibu na-etolite ihe owuwu dị mgbagwoju anya nke ihe ngwọta ahụ, nke na-abawanye esemokwu nke ihe ngwọta ma na-eduga na mmụba na viscosity. N'otu oge ahụ, nnukwu ihe molecular ga-ebute mgbanwe mgbanwe siri ike na ngwọta n'oge usoro na-asọpụta, nke dị ezigbo mkpa maka ịhazi arụmọrụ nke mkpuchi, adhesives na ngwa ndị ọzọ. Ma nnyocha ma nnyocha nyocha na usoro mmụta egosila na ogo HPMC ike na-egosipụta ike mmekọrịta, ya bụ, ọhụụ anaghị abawanye nwayọ dịka oke molecularị na-abawanye.
2. Mmetụta nke ogo nke dochie
Ogo nke nhichapụ nke hydropyyl (-Ch3chohch2-) na methyl (nke bụ isi bụ ihe dị mkpa na-emetụta mmụọ ya na viscosity. Ogo nke dochie anya nke na-ezo aka na otu hydroxy dị iche iche (-OH) na HPMC molecular yinye hydroxyyl na Methyl. Mgbe ogo nke otu hydropyyyyyl na-abawanye, mmekọrịta dị n'etiti Hpmc molecular a ga-abawanye, ma a ga-adịrị m mma ma na-amụba na viscosis nke ihe ngwọta ahụ; Ọ bụ ezie na mmụba nke otu methyl ga-abawanye hydrophobity nke ihe ngwọta ahụ, na-ebutekwa solkation na-ebelata, si otú ahụ na-emetụta Visity. N'ozuzu, hpmc na ogo dị elu nwere ike dị elu na viscosity, ma nwee ike mezuo mkpa viscosit nke ala viscositso nke mpaghara viscositso nke mpaghara viscositso.
3. Mmetụta nke itinye uche
Nleta viscosity nke HPMC Ngwọta nwere njikọ chiri anya na ntinye ya. Dị ka ịta nke ihe ngwọta na-abawanye, mmekọrịta dị n'etiti ụmụ irighiri ihe na-abawanye nke ukwuu, na-akpata viscosity nke ngwọta. Na ala dị ala, ụmụ irighiri akwara HPMC dị n'ụdị otu, na nka na-agbanwe agbanwe nke ọma; Mgbe ịta ahụ ruru uru dị mkpa, ụmụ irighiri ihe dị mkpa, ha ga-ebido ma na ibe ha na-emekọrịta ihe, na-akpụ nhazi netwọdi, na-akpata viccosict victy ịbawanye ngwa ngwa. Na mgbakwunye, mmụba na ntinye uche ga-akpatakwa HPMC iji gosipụta Shee Shee There, ya bụ, visses ga-abawanye n'okpuru oke nke nnukwu osisi.
4. Mmetụta nke ụdị ihe mgbaze
Typedị nke ihe mgbaze nwekwara mmetụta dị mkpa na solubality na viscosity nke HPMC. Enwere ike ịgbasa hpmc na mmiri na ụfọdụ ihe mgbazinye ihe ụfọdụ (dị ka Methanol, ettanol, acetone), mana ndị na-agba mbọ dị iche iche nwere ndọtị dị iche iche. Na mmiri, HPMC na-adịkarị n'ụdị viscosity dị elu, ebe na sosganic na-egosi obere viocosity. Polarity nke onye na-ahụ maka ihe mgbaze ahụ nwere mmetụta dị ukwuu na viscosity nke HPMC. Sọọ nkwado nwere polarity dị elu (dịka mmiri) ga-eme ka hydration nke ụmụ irighiri ihe nke Hpmc, na-abawanye viscosis nke ihe ngwọta. Solvents na-abụghị nke polar enweghị ike igbachapụ HPMC, na-eme ka ihe ngwọta gosipụta obere vicosity ma ọ bụ mgbasa zuru ezu. Ke adianade do, nhọpụta na oke ngwakọta na-egbu egbu ga-emetụtakwa arụmọrụ viccosict arụmọrụ nke HPMC.
5. Mmetụta nke okpomọkụ
Ọnọdụ okpomọkụ bụ otu n'ime ihe ndị dị mkpa metụtara gburugburu ebe obibi na-emetụta viseria nke HPMC. N'ozuzu, viscosity nke Hpmc na-ebelata dị ka okpomọkụ na-abawanye. Nke a bụ n'ihi na oke okpomọkụ ga-emebi nke agbụ na mkparịta ụka ndị ọzọ n'etiti ụdị Hpmc, na-eme ka eriri molecular slide karịa, si otú a belata vide ahụ nke ihe ngwọta. N'oge ụfọdụ dị elu, Hpmc nwere ike ịbụ na ị ga-enwe mgbatị ahụ iji mepụta usoro netwọkụ nke GEL. A na-eji ihe ndị a na-ere ọkụ na-eji ọtụtụ ihe na ụlọ ọrụ na ụlọ nri dị ka ọ na-enye ọhụụ viccosity na nhazi nhazi. Na mgbakwunye, okpomọkụ nwere mmetụta dị iche iche na viscosity hpmcs nwere ihe dị iche iche molecular dị iche iche. N'ozuzu, hpmcs nwere nnukwu molecular nnukwu molecular dị elu na-emetụta mgbanwe okpomọkụ.
6. Mmetụta nke uru PH
Ọ bụ ezie na HPMC bụ polymer na-anọpụ iche na ọ na-echekwa mgbanwe pzọ, enwere ike imetụta viscosis ya n'okpuru acid plọ (dị ka gburugburu actine). Nke a bụ n'ihi na acid ma ọ bụ gburugburu alkali siri ike ga-ebibi ihe owuwu nke HPMC ma belata nkwụsi ike ya, nke na-ebute mbelata na viscosity. Maka ụfọdụ ngwa, dị ka nkwadebe ọgwụ na ihe mgbakwunye nri, njikwa nke gị dị oke mkpa iji hụ na viscs viscosity hpmc na-adịgide adịgide n'ime oke.
7. Mmetụta nke ike Ionic
Ike ionic na ihe ngwọta na-emetụtakwa omume viscositse omume HPMC. Ebe obibi nke Ionic ga-achụgharị na eriri dị na hpmc molecular ígwè hpmc, na-ebelata ihe mkpuchi electrostatic n'etiti ụdọ mmiri, na-eme ka ọ dịkwuo mfe ịzọ, site na ibelata viscosity. Na mkpokọta, mgbe a ga-achịkwa usoro nke HPMC, a ga-achịkwa ion itinye uche iji hụ na viacScosity na-enweghị atụ, nke dị mkpa karịsịa na usoro ọgwụgwọ ọgwụ.
Ọtụtụ ihe, gụnyere oke molecular, ogo ihe eji arụ ọrụ, ịta ihe ngwọta, ụdị ihe mgbaze, ụdị nke oke na ike ionic. Igodo na ogo nke dochie anya na-ekpebi njirimara vissic nke HPMC, ebe ọnọdụ mpụga dịka ịta ahụhụ, ụdị ihe mgbaze na ọnọdụ okpomọkụ na-emetụta arụmọrụ viscosictosict na ngwa ọdịbe. N'ime ihe ndị dị mma, ụdị HPMC kwesịrị ekwesị na ọnọdụ njikwa kwesịrị ka ịhọrọ usoro akọwapụtara iji nweta arụmọrụ viscosity arụmọrụ. Mmekọrịta nke ihe ndị a na-ekpebi arụmọrụ na mpaghara HPMC, na-enye nkwado ụkpụrụ maka ngwa ya na ụlọ ọrụ, ọgwụ na ọrụ ndị ọzọ.
Oge post: Feb-15-2025