Ihe na-emetụta viscosity nke hydroxypropyythylthyl

Hydroxypylthylthylcelllose (hpmc) bụ osisi okike na-ejikarị nri, ọgwụ, ihe ịchọ mma na ubi ndị ọzọ. Ọ bụ viscosity ya bụ ihe ngosipụta dị mkpa na-emetụta arụmọrụ ya, nke na-emetụtakarị ihe ndị dị ka molecular arọ nke HPMC, itinye ihe nledo, ụdị ihe mgbaze na ọnọdụ okpomọkụ.

1.
Ibu akwara nke Hpmc bụ otu n'ime ihe ndị ka mkpa metụtara ya. N'ikwu ya n'ozuzu, ka ibu akwara, ogologo oge nke Hpmc, ihe ka njọ na visce. Nke a bụ n'ihi na nhazi nke macromecular ▪ discrecular na-enye ndị ọzọ mmekọrịta, na-ebute ihe mgbochi siri ike na mmiri nke ihe ngwọta. Ya mere, n'otu ngwọta ahụ, ihe ngwọta HPMC nwere oke mowoolar na-egosipụtakarị ọhụụ vita.

Mmụba na oke molecular na-emetụtakwa Njirimara viscoelastic nke ihe ngwọta. Ngwọta HPMC nwere oke molecular na-egosipụta ike visa Visasticty na ọnụego Shear, ebe ọnụego Shear ha nwere ike ịkpa oke dịka mmiri mmiri Newtontian. Nke a na-eme HPMC nwere omume rapiocal dị mgbagwoju anya na ọnọdụ dị iche iche.

2. Ngwọta Ngwọta
Nta nke ihe ngwọta nwere mmetụta dị ukwuu na viscosity nke HPMC. Dị ka ịta nke HPMC na-abawanye, mmekọrịta dị n'etiti molecules na ngwọta na-abawanye, na-ebuwanye iguzogide na-asọpụta ma si otú ahụ abawanye na viscosise. N'ikwu okwu, ịta nke hpmc na-egosi uto na-enweghị isi n'ime otu ụdị, ya bụ, ọnụego nke viscitse na-abawanye na ịta nke ọma.

Karịsịa na ngbanwe dị elu, mmekọrịta dị n'etiti elucs dị ike, ihe owuwu netwọọk ma ọ bụ gleletion nwere ike ime, nke ga-emewanye viccosise nke ihe ngwọta. Ya mere, na ngwa ọrụ ngwa, iji nweta njikwa ezigbo viscosity, ọ na-adịkarị mkpa iji mezie ntinye nke HPMC.

3. Typentdị ihe mgbu
Ngalaba na visse nke HPMC nwekwara njikọ na ụdị nke ihe mgbal. HPMC na-ejikarị mmiri dị ka ihe mgbaze, mana ọnọdụ ụfọdụ akọwapụtara, ihe mgbaze ndị ọzọ dịka ethanol na acetone na acetone. Mmiri, dị ka polar lekwasịrị anya, nwere ike imekọrịta nke ukwuu na hydroxy na methy na HPMC Molecules iji kwalite mgbasa ya.

Poaraty nke ihe mgbaze, ọnọdụ okpomọkụ, na mmekọrịta dị n'etiti ihe mgbaze na ụmụ irighiri ihe na HPMC ga-emetụta mbọ na viscosity nke HPMC. Dịka ọmụmaatụ, a na-eji ihe mgbaze dị ala na-eji, ngbanwe nke Hpmc mbelata, nke na-ebute na viscosity nke ihe ngwọta.

4. Okpomoku
Mmetụta nke okpomoku na viscosity nke HPMC dịkwa mkpa. N'ozuzu, viscosity nke ngwọta HPMC na-agbadata na oke okpomọkụ. Nke a bụ n'ihi na mgbe ọnọdụ okpomọkụ na-abawanye, molecular ikuku na-abawanye, na-ebute ike nke ike mmekọrịta n'etiti moleculs, si na-ebelata viscosity.

Na ụfọdụ ọnọdụ okpomọkụ, Njirimara Njirimara HPMC gosipụtara omume mmiri na-abụghị nke ọhụụ, ya bụ, ọ bụghị naanị na ọnụego osisi emetụtaghị mgbanwe okpomọkụ. Ya mere, na ngwa bara uru, na-achịkwa mgbanwe okpomọkụ bụ otu n'ime ụzọ dị irè iji dozie viscosity nke HPMC.

5. Ọnụego Shear
Vieocosis nke HPMC abụghị naanị ihe ndekọ site na usoro static, kamakwa site na ọnụego ya. HPMC bụ mmiri mmiri na-abụghị ndị Newtontian, na mgbanwe mgbanwe ya na mgbanwe nke ọnụego shiu. N'ikwu okwu, HPMC Ngwọta na-egosi viscosity dị elu na ọnụego Shear, ebe vieresese na-ebelata ihe dị mkpa na ọnụego Shear. A na-akpọ onye a na-eme ihe nkiri na-acha uhie uhie.

Mmetụta Shear na viscosity nke HPMC na-abụkarị ihe metụtara omume na-aga n'ihu nke eriri molec. Na ala Shiar, agbụ molecular na-etinye ọnụnọ ọnụ, na-ebute ọhụụ viacosity; Na elu Shiar, mmekọrịta dị n'etiti elucs na-agbaji na viscosity dị ala.

6. Ph uru
Viscosity nke HPMC nwekwara njikọ na uru pH nke ihe ngwọta ya. HPMC Molecules nwere usoro hydroxypyl na methyl, na ebubo ọnọdụ ndị otu a na-emetụta. Na ụfọdụ pọpụ, ụmụ irighiri akwara nwere ike ịtaze ma ọ bụ ụdị gels, si otú ahụ gbanwee viscosit nke ihe ngwọta.

N'ozuzu, gburugburu alkaline, ihe owuwu HPMC nwere ike ịgbanwe, na-emetụta mmekọrịta ya na ụmụ irighiri ihe na-agbanwe agbanwe ma, n'aka nke ya, na-emetụta viscosict. Na ụkpụrụ plọl dị iche iche, nkwụsi ike nke ngwọta HPMC nwekwara ike ịdị iche, yabụ nlebara anya pụrụ iche na njikwa PH dị.

7. Mmetụta nke ihe mgbakwunye
Na mgbakwunye na ihe ndị a dị n'elu, ụfọdụ ihe mgbakwunye dị ka nnu na ndị na-asa ahụ nwekwara ike imetụta viscosity nke HPMC. Mgbakwunye nke nnu nwere ike ịgbanwe ike ionic na-agbanwe ike nke ihe ngwọta ahụ, si otú ahụ na-emetụta ngụgụ na viscosity nke molecosis. Surfacts nwere ike ịgbanwe usoro nke HPMC site na ịgbanwe mmekọrịta dị n'etiti ụmụ irighiri ihe, si otú ahụ gbanwee viscosity ya.

A na-emetụta viscosity nke HPMC, gụnyere oke molecular, ịta ihe nledo, ụdị ihe mgbaze, oke oke, uru ya na ihe mgbakwunye. Iji jikwaa njirimara viscosict nke HPMC, ọ dị mkpa idozi ya n'ụzọ ziri ezi dịka ihe achọrọ ngwa. Site na nghọta ihe ndị a na-emetụta, arụmọrụ nke HPMC nwere ike ịhọrọ ọnọdụ dị iche iche na ọnọdụ iji hụ na nkwụsi ike na ngwa dị iche iche.