Ike na ihe ịma aka nke iji HPMC

Hydroxypylmethylcelllose (HPMC) bụ polymer na-ejikarị ụkpụrụ ọgwụ n'ihi ọdịdị ya, biocompatatisical Njirimara. Ma, ntinye ya enweghị ihe na-enweghị ike na nsogbu. Na-agụnye akụrụngwa physochemical, nhazi ihe ịma aka, ihe nkwụsi ike, akụkụ iwu na ndị ọzọ na-apụta. Ghọta mgbochi ndị a dị oke mkpa maka ndị nyocha na ndị na-emepụta ọgwụ iji merie ihe mgbochi ma bulie arụmọrụ nke usoro nke HPMC.

Hydroxympylmethylcelllose (HPMC) bụ ihe eji egbu egbu na-ejikarị na usoro ọgwụgwọ n'ihi oke nke ojiji n'ihi ogo ya, na nza nke viefier, ma na-achịkwa ọrụ nlegharị anya. N'agbanyeghị amamịghe ya ewu ewu, iji HPMC na-egosi ụfọdụ adịghị mma na nsogbu ndị dị mkpa ka a gwa ya maka mmepe usoro na azụmaahịa.

Ngwongwo ndị na-egosi na kemịkalụ:
HPMC nwere ihe ngosi physicochemidical pụrụ iche, dị ka ngụgụ, vissity, na omume na-akpata ya, nke dị mkpa maka arụmọrụ ya na usoro iwu ọgwụ. Agbanyeghị, njirimara ndị a nwekwara ike ịmepụta nsogbu ndị ọzọ. Iji maa atụ, viscosity ngwọta nke hpmc na-adabere na ihe dị ka okpomọkụ, pH, na ọnụego ya, nke nwere ike imetụta Njirimara Njirimara n'oge nrụpụta. Na mgbakwunye, ngbanwe nke HPMC nwere ike igbochi ngwa ya na usoro nnyefe ọgwụ, ọkachasị n'ụdị mgbasa dị ngwa ngwa.

2..
Nhazi nke HPMC nwere ike ịbụ ihe ịma aka n'ihi hygroscopity ya dị elu na ezi uche dị na ọnọdụ gburugburu ebe obibi. Hygroscopicity nwere ike ibute nsogbu dịka akụrụngwa na-agagharị na ngwa agha na-agagharị n'oge na-emepụta ihe dị ka granilation na mbadamba. Ọzọkwa, mmetụta nke HPMC iji gbanwee na ọnọdụ okpomọkụ na iru mmiri chọrọ njikwa nhazi iji hụ na Unityritylọ Ọrụ na nkwụsi ike.

3. NSOGBU NIILE:
Kwụsị bụ akụkụ dị oke mkpa nke usoro ọgwụ, na HPMC nwere ike ịkọwa ụfọdụ nsogbu siri ike, ọkachasị na sistemụ olulu. Iji maa atụ, HPMC nwere ike itinye hydysis n'okpuru ọnọdụ acidic, na-eduga ngọngọ mebiri emebi na ike nke nwere ike gbanwee na akụrụngwa usoro. Ọzọkwa, mmekọrịta n'etiti HPMC na ihe ndị ọzọ na-eme ka ọgwụ (APIS) nwere ike imetụta nkwụsi ike nke ngwaahịa ikpeazụ, na-egosi mkpa maka agụmakwụkwọ inflatisting n'oge mmepe mmepe.

4. Nlekọta:
Ọnọdụ nhazi ahụ gbara ya gburugburu iji HPMC na-eme ọgwụ bụ ihe ọzọ a ga-atụle. Ọ bụ ezie na HPMC na-ewere nchekwa nchekwa (Gras) site na ụlọ ọrụ nhazi dịka FDA, enwere ike inwe ihe ndị akọwapụtara ma ọ bụ mmachi eji arụ ọrụ. Ọzọkwa, mgbanwe na nduzi ma ọ bụ ụkpụrụ nhazi nwere ike imetụta usoro ma ọ bụ usoro nnabata maka ngwaahịa ngwaahịa HPMC, chọrọ nnabata na mbọ ndị na-emepụta.

5. Ndị ọzọ na-apụta:
Nyere oke na nsogbu nke HPMC, ndị na-eme nchọpụta na ndị nrụpụta na-enyocha polymers ọzọ na ntụgharị maka usoro ọgwụgwọ ọgwụ. Ndị ọzọ ndị a nwere ike inye uru dị ka nkwụsi ike na-akawanye njọ, ma ọ bụ belata ihe ịma aka nhazi. Ihe atụ gụnyere ihe atụ nke mkpụrụ osisi cellyllose ma ọ bụ methylcellose, na pro polyvinyl mmanya (PVA) ma ọ bụ polyethylene glycol (peg). Agbanyeghị, ojiji ndị ọzọ expifas chọrọ nyocha nke nchekwa ha, nrụpụta, na ndakọrịta na ihe ndị ọzọ na usoro.

Hydroxypylmethylcelllose (hpmc) bụ polymer bara uru n'ịrụpụta ọgwụ, mana ojiji ya enweghị ike na nsogbu. Nghọta na ịza oke ndị a dị oke mkpa iji mepụta arụmọrụ na nkwụsi ike nke ngwaahịa HPMC. Site n'iche echiche nke ọma na akụrụngwa phycochemidical, mbipụta nsogbu, akụkụ stesictives, na ndị ọzọ na-eme nchọpụta nwere ike imeri ihe mgbochi ma mee ka ngwa na-eme ọgwụ.