News - Nkwadebe na Njirimara nke Hydropyythylthylthylthyl

Hydroxypylthththththylcelllose(HPMC) bụ polymer polymer nwere ọtụtụ ihe onwunwe, mmeghari, na ezigbo mmiri na ihe ndị na-akpụ akpụ. Ọ bụ ihe kachasị mma nke akụrụngwa maka nkwadebe nke fim na-agbanye mmiri.

Ihe nkiri ngwugwu mmiri bụ ụdị nke ngwugwu ngwugwu ọhụụ, nke na-enweta nlebara anya na Europe na United States na mba ndị ọzọ. Ọ bụghị naanị na ọ dị mma ma dịkwa mfe iji, kamakwa edozi nsogbu nke mbukota mkpofu. Ka ọ dị ugbu a, ihe nkiri na-eme mmiri kachasị na-eji ihe ndị dabeere na mmanụ dị ka mmanya polyvinyl na polyethylene oxide dị ka akụrụngwa. Petroleum bụ akụ na-adịghị emeghachi omume, na nnukwu ọrụ ga-eme ka ala mgbasa ozi. Enwekwara ihe nkiri na - eji ihe nkiri sitere na iji ihe ndị dị na starch na protein dị ka akụrụngwa, mana ihe nkiri ndị a na - agbanye mmiri na - agbanye mmiri na - agbaze. Na mpempe akwụkwọ a, a kwadebere ụdị ihe nkiri ngwugwu nke mmiri mmiri site na ngwọta nke na-egosi usoro ihe nkiri na-eji usoro ihe nkiri na-eji hydroxyylthylthylthylllthylthylthylthylllthylthylthylthylthylthylthylthylthylthylthylthylthylthylthyl. A tụlere nsonaazụ nke mmiri mmiri Hpmc na ihe nkiri na-eme ihe nkiri na ike tensile, Elongation na-agbaji, ngbanwe ọkụ na mmiri na-agbanye mmiri mmiri na-agbanye mmiri. Ejiri ya na glercel, sorbil na glutaldehyde mee ka arụmọrụ nke fim HPMC na-agbanye. N'ikpeazụ, iji gbasaa ngwa nke ihe nkiri HPMC nke mmiri na-egbochi ihe oriri, asịrị antioxident (Abnoo) iji meziwanye ihe nkiri antioxidant nke fim mmiri HPMC. Nchọpụta bụ isi bụ ndị a:

(1) Site na mmụba nke ịta ahụhụ, ike tens na oge ezumike nke fim HPMC mụbara, ebe ụgbọ mmiri ọkụ ahụ belatara. Mgbe HPMC ịta bụ 5% na ihe nkiri ahụ na-akpụpụta okpomọkụ bụ 50 Celsius C, Njirimara nke ihe nkiri HPMC dị mma. N'oge a, ike tensile dị ihe dị ka 116MPA, Elongation na ezumike bụ ihe dị ka 31%, transminance ọkụ bụ 90%, na mmiri na-ajụ 55min.

(2) Ihe nkiri fọdụrụnụ glycerlol na-eme ka ihe nkiri nke fim HPMC mere ka ọ dịkwuo elu na ezumike. Mgbe ọdịnaya nke glycerlol dị n'etiti 0.05% na 0.25%, nsonaazụ ahụ kachasị mma, na mbara igwe na-agbasa ihe nkiri HPMC-soluble mmiri ruru 50%; Mgbe ọdịnaya Sorbitlol bụ 0.15%, Elongation na-abawanye na 45% ma ọ bụ karịa. Mgbe agbanwere ihe nkiri na-emepụta mmiri HPMC - na-agbanye na Glycellol, ike tens na ngwa ọdịnala belatara, mana mbelata abụghị ihe dị mkpa.

(3) Ihe nkiri na-emegharị nke glutaldehyde-soluble mmiri na-agbanye na fim ahụ, na -ebelata akụkụ mmiri nke ihe nkiri mmiri HPMC. Mgbe mgbakwunye nke glutardehyde bụ 0.25%, akụrụngwa akụrụngwa na ngwa ọdịnala nke fim ahụ ruru kachasị. Mgbe mgbakwunye glutaldehyde bụ 0.44%, oge mmiri na-ajụ 305 min.

(4) na-agbakwunye ego kwesịrị ekwesị nke AOB ka HPMC mmiri na-emepụta ihe nkiri na-eme ihe nkiri na-eme ihe ga-eme ka ihe nkiri na-egbochi antioxidant nke fim ahụ. Mgbe agbakwunyere AOB, ihe nkiri AOB / HPMC nwere ọnụego ihe dị ka 89% maka ihe nkiri DPMC dị mma karịa nke ihe nkiri HPMC na-enweghị nke ọma.

Okwu okwu: ihe nkiri ngwugwu mmiri; hydroxypylth methylcellose; plastizer; Onye na-eme ka ihe nnọchi anya; antioxidant.

Tebulu ọdịnaya

Nchịkọta .............................. ............................................................

Na-egbochi ................................................................................................. ihe

Tebulu ọdịnaya…………………………………………. ......................................................................

ISI NKE OMOKPERE ............................................ ............................................. ..1

1.11 MGBE NSOGBU NSOGBU EGO ..............................................................................................................................................1

Ihe nkiri 1.1.1.................................................. 1

1.1.2polyetyyleneyyme ihe nkiri (ndị mmadụ)

1.1.3starch nke ihe nkiri sitere na ihe nkiri 1.1.................................................... .2

1.1.4 Ihe nkiri na-eme nke sitere na mmiri (na-esote protein na-eme protein )................................................ .2

1.2 Hydroxylthylthylthylylthylylylylylylylylllose ................................................................

1.2.1 Ọdịdị nke Methylcellose ........................................................... .3

1.2.2 Mmiri nke Hydropyyylpypyl Methylcelllose ...................................................... 4... 4

1.2.3 Ngwongwo na-akpụ akpụ nke Hydropyylmylylthylcelllose .............................................

1.3 Nghapu fọdụrụ nke ihe nkiri Hydyypyl Methylcellose ........................ ..4

1.4 Mgbanwe nke Nchọgharị Hydypypyl Methylcellose ............................ .5

1.5 antioxidive Ngwongwo hydypypylthylcelllose ............................ 5.

1.6 Nhazi isiokwu a ........................................................................................... .......................................... .7

1.7 Ọdịnaya Nchọpụta ....................................................................................................

Isi nke 2 na nkwadebe hydyppyl methyppyl na-eme ihe nkiri na-egbochi ihe nkiri mmiri mmiri na-egbochi mmiri mmiri na-egbochi mmiri mmiri.

2.1 Mpịakọta ................................................................................................ M

2.2 Akụkụ nnwale ............................................................ ........................................ .8

2.2.1 ihe na akụrụngwa na akụrụngwa ..................................................................................... ......... ..8

2.2.2 Nkwadebe Dị Ndozi ........................................................................................9

2.2.3 Nnwale Nnwale na Nnwale arụmọrụ ........................................................... .9

2.2.4 Nhazi data ..................................................... .............................................. 10

2.3 nsonaazụ na mkparịta ụka .............................................................................................. .........

2.3.1 Mmetụta nke usoro ihe nkiri na-eme ka ihe nkiri HPMC dị mkpa na Hpmc dị mkpa fim .............................................................................................................................................................................................................................................................................................__________________........... 10

2.3.2 Mmetụta nke ihe nkiri na-eme ihe nkiri na hpmc dị mkpa fim na Hpmc :....................................................................................1..1..1

2.4 Nchịkọta isia ............................................................ 16

Isi nke 3 nke fstizers mmiri na-egbochi ihe nkiri HPMC nke na-egbochi mmiri na-emepụta ihe nkiri HPMC.

3.1 Okwu Mmeghe ........................................................................................................................................................ 17

3.2 Akụkụ nnwale ............................................................................................ ......... ..17

3.2.1 Ihe nlere na akụrụngwa ...................................................................................

3.2.2 Nkwadebe Dị Ndozi ...............................................................

3.2.3 Nnwale na nnwale arụmọrụ .................................................... .18

Nhazi data 3.2.4.................................................................... ............................... ..19

3.3 Ihe na Mkparịta ụka na mkparịta ụka ...................................................................................... 19

3.3.1 Mmepụta nke Glycerlol na Sortram Actrarption Styrad Films HPMC Trick Films nke HPMC Oring Film Firms nke HPMC Oro This This :....................................................................................................................................................................................

3.3.2 The effect of glycerol and sorbitol on the XRD patterns of HPMC thin films ……………………………………………………………………………………………………………………………………..20

Ihe nkiri 3.3.3 nke Glycerlol na Njirimara Njirimara nke HPMC Njirimara nke HPMC Mkpa Forms Njirimara ......................................

Ihe nkiri 3.3.4 nke Glycerlol na ngwa ngwa nke ihe nkiri HPMC na-eme .........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................__________________...................

3.3.5 Mmetụta Glycellol na sornol na mmiri nke fim HPMC .......... 23

3.4 Nchịkọta isia ........................................................................................ ...24

Isi nke 4 na-egbochi ihe nkiri na-egbochi ihe nkiri HPMC nke mmiri

4.4 Mmeghe .......... 25

4.2 Akụkụ nnwale ........................................................................................ 25

4.2.1 Ihe omuma na ngwa ............................................................

4.2.2 Nkwadebe Dị Ndozi ..................................................................26

4.2.3 Nnwale na nnwale arụmọrụ ............................................ ..26

4.2.4 Nhazi data ........................................................................... .....................................26

4.3 Mmepụta na mkparịta ụka .....................................................................................................

4.3.1 Nnọkọ ActraalPred Abrimpyde nke Glutardehyde Ngwongwo ympy-CrossLed HPMC Oro - Crowllinked HPMC Oro - Crowllinked Hpmc Filts Hpmc :.................................................................................................................................................. .....27

4.3.2 xrd usoro nke glutardehyde crords hpmc confter fim ................................27

4.3.3 Mmetụta Glutardehyde na Mmiri Njedebe nke Ihe nkiri HPMC .......................28

4.3.4 Mmetụta Glutardehyde na Njirimara Njirimara nke HPMC Try Firms ... 29

4.3.5 mmetụta nke glutalaldehyde na ngwa ngwa ihe nkiri HPMC ................9

Ndepụta isiakwụkwọ ............................................................... .. 30

Isi nke 5

5.1 Okwu Mmeghe ....................................................

5.2 Nka mbụ ....................................................................................................

5.2.1 Ihe omuma na ihe nyocha na ngwa agha .............................................. 31

5.2.2 Nkwadebe ụdị ................................................................................ .32

5.2.3 Nnwale arụmọrụ na nnwale arụmọrụ ........................................................ 3 23

5.2.4 Nhazi data ............................................ ............................................ 33

5.3 Mmepụta na nyocha ..................................................................................................33

5.3.1 Nchịkwa Ahịa .................................................................................................................................... 33

5.3.2 XD na nyocha ....................................................................................................34

5.3.3 Njirimara Antioxidant .................................................................................... 34

5.3.4 Sọlings Sọ Okwu ............................................................................................35

5.3.5 Ngwongwo igwe ihe .................................................................................... ...36

5.3.6 arụmọrụ .................................................................... 37

5.4 Nchịkọta nke Nchịkọta .................................................................................... ..........37

Isi nke 6 kwubiri ........................................ ................................ ....39

Ebe e zoro aka ............................................................................................ 40

Nchoputa n'oge omumu ihe omumu ...................................................... ..44

Ghọta ...................................................................................... ..46

Isi Okwu Mmeghachi

Dị ka ihe nkiri ngwugwu akwụkwọ ndụ akwụkwọ ndụ, a na-ejikarị ihe nkiri na-eme achịcha na-atọ ụtọ na nkwakọ ngwaahịa nke ngwaahịa dị iche iche na mba ndị ọzọ (dịka United States, France, wdg) [1]. Ihe nkiri mmiri na-ada, dị ka aha ahụ pụtara, bụ ihe nkiri rọba nke nwere ike ịgbasa na mmiri. Ejiri ihe polymer mmiri mee ya nke nwere ike igbari na mmiri ma kwadebe site na otu usoro na-akpụ akpụ. N'ihi ihe ndị pụrụ iche ya, ọ dị mma nke ukwuu maka ndị mmadụ ka ibe. Ya mere, ọtụtụ ndị na-eme nchọpụta amalitela ị attentiona ntị n'ihe ndị ahụ nchebe na ịdị mma [2].

1.1 mmiri na-eme mmiri

Ka ọ dị ugbu a, ihe nkiri na-eme mmiri na-eji ihe na-eme mmiri na-eji ihe ndị dakwasịrị na polyvinyl na-egbu egbu na polyethyle oxide dị ka stachi na protein dị ka akụrụngwa.

1.1.1 polyvinyl mmanya (PVA)

Ka ọ dị ugbu a, ihe nkiri a na-eji mmiri mmiri na-ejikarị n'ụwa bụ ihe nkiri PVA nke mmiri. PVA bụ polyl polyl nke nje nwere ike iji ya na isi mmalite pocbon na-eme ihe, nke na-enwe obere ụdị ihe dị ala, na-eguzogide na ihe mgbochi mgbochi gas. Ihe nkiri PVA nwere ezigbo ihe eji arụ ọrụ arụ ọrụ, ime mgbanwe siri ike na nchebe dị mma gburugburu ebe obibi. A na-eji ya eme ihe n'ọtụtụ ebe ma nwee ezigbo azụmahịa. Ọ bụ site na tere aka na-ejikarị ihe nkiri ngwugwu mmiri na-agbanye mmiri na ahịa [5]. PVA nwere ezigbo nrụpụta ma enwere ike ibute ya site na microorganisms microorganisms iji mepụta CO2 na H2O na ala [6]. Imirikiti ihe nyocha ahụ na ihe nkiri na-eme mmiri ugbu a bụ gbanwee ma gwakọta ha iji nweta fim na-soluzi. Zhao Linun, Xoong Hanguo nke ihe nkiri na-egbochi ya na PVA dị oke ọnụ (oxycen 5%, glycen 5%, sodium dodecyl sulfate (SDD) 4%. Mgbe microwave nkụ nke ihe nkiri a nwetara, mmiri na-agbanye mmiri na mmiri n'ụlọ okpomọkụ bụ 101.

Na-ekpe ikpe site na ọnọdụ nyocha dị ugbu a, a na-eji ihe nkiri PVA n'ọtụtụ ebe, ọnụ ahịa dị ala, na ọmarịcha ya na Njirimara dị iche iche. Ọ bụ ihe eji eme oriri na nkwari mmiri. Agbanyeghị, dị ka ihe dabeere na mmanụ, PVA bụ ihe na-anaghị emeghachi omume, enwere ike imetọ ihe mmepụta ya. Ọ bụ ezie na United States, Japan na mba ndị ọzọ edepụtala ya dị ka ihe na-abụghị ihe na-adịghị mma, nchekwa ya ka na-emeghe ajụjụ. Ma imi na ingesting na-emerụ ahụ mmadụ [8], enweghị ike ịkpọ ya nke ọma na-acha akwụkwọ ndụ akwụkwọ ndụ zuru ezu.

1.1.2 polyethylene oxide (ndị mmadụ) ihe nkiri

Pollethylene Oxide, nke a makwaara dị ka oxicylene oxide, bụ mmiri polymer nwere ike ịgwakọta ya na mmiri ọ bụla n'ụlọ okpomọkụ [9]. Usoro nhazi nke polyethylene oxide bụ h - (- OCH2CH2-) N-Oh, Mass mụ na ya ga-emetụta ihe owuwu ya. Mgbe ịdị arọ molecular dị na ogo nke 200 ~ 20000, a na-akpọ ya polyethylene glycol (a ga-akpọ oke molethylene oxide (ndị mmadụ). Ndị mmadụ bụ ntụ ntụ na-asọ oyi, nke dị mfe iji usoro ma dị mfe. A na-akwadebe fim ndị ahụ site na ịgbakwunye fọdụrụnụ, ndị na-ekwuchi ya na filters ndị dị iche iche na-emegharị site na nhazi ikuku [11].

Screen fim bụ ihe nkiri na-agbanye mmiri nwere ezigbo mmiri sos, yana usoro arụmọrụ ya, nke nwere mmetụta na ọnọdụ na gburugburu ebe obibi, nke nwere ike iji ya na gburugburu. Ọdị ihe nkiri PVA [12]. Na mgbakwunye na, ndị mmadụ nwekwara ọmịiko ụfọdụ, n'ihi ya, a naghị eji ya eme ihe na nkwakọ ngwaahịa [13].

1.1.3 mmiri na-acha uhie uhie

Starch bụ polymer dị elu molecular dị elu, na ụmụ irighiri akwara nwere ọtụtụ ndị na-enweghị atụ, yabụ na stachi siri ike gbazee, ya mere, ọ na-esiri ike iso ndị ọrụ polymers ndị ọzọ. hazie ọnụ [14,15]. Mpaghara steepụ, ọ na-ewe ogologo oge iji tụba mmiri oyi, nke ahụ na-agbanwe agbanwe, ya bụ, stachi starch, na-abụkarị iji kwadebe ihe nkiri na-eme mmiri. N'ozuzu, starch bụ n'ụzọ mmiri dị ka usoro dị ka Esemokwu dị ka Esemokwu, Igwe ọka, na njikọta nke stachi, wee mee ka ịhazi mmiri nke stachi [7,16].

Jiri akara eji eme ihe na-eme ka ọ bụrụ ihe dị iche iche na kemịkal dị iche iche ma ọ bụ jiri arụmọrụ dị mma na-eme ka ọ dị mma. Agbanyeghị, na obere okpomọkụ, ihe nkiri stachi nwere ezigbo ndị na-adịghị mma na nghọta na-adịghị mma, yabụ, ọ dị mkpa ịkwadebe ya site na iji ihe ndị ọzọ dị ka PVA, yana uru iji ya eme ihe adịghị elu.

1.1.4 Mkpịsị ugodi na-eme ka mmiri sie ike

Protein bụ ihe na-arụ ọrụ nke ọma macromecular dị na anụmanụ na osisi. Ebe ọ bụ na ọtụtụ protein na mmiri na mmiri n'ime ụlọ okpomọkụ, ọ dị mkpa iji dozie soliin na mmiri na-agbanye mmiri. Iji meziwanye nke protein, ha kwesịrị ịgbanwe ha. Usoro mgbanwe kemịkalụ kemịkalụ kemịkalụ, Phhalodid, phosphorylation, wdg. [Foto dị na peeji nke 18; Mmetụta mgbanwe bụ ịgbanwe ihe owuwu anụ ahụ, si otú ahụ na-abawanye ike sọrọb, na arụ ọrụ dị ka mmiri mmiri na nkwụsi ike na-egbo mkpa nke imepụta na nhazi. Enwere ike ịmepụta ihe nkiri protein site na iji ngwa ahịa ọrụ ugbo dị ka akpịrị ịkpọ akụ dị ka akụrụngwa, ma ọ bụ site na mmepụta nke ụlọ ọrụ dị elu, na ihe ndị a na - eme mgbanwe na gburugburu ebe obibi [19]. Agbanyeghị, fim-soluble na-akwadebe site na otu protein dị ka ihe matriks nwere akụrụngwa nke na-adịghị mma na mmiri dị ala na obere mmiri na obere okpomọkụ ma ọ bụ okpomọkụ ha dị warara.

Rekọtara ọnụ, ọ bụ ihe dị mkpa iji zụlite ọhụụ, ihe nkiri na-emeghari, na-agbanye mmiri na-eme ka ọ dị mma iji meziwanye ihe nkiri nke ihe nkiri nke mmiri dị ugbu a.

Hydroxypyl Methyl Cellulose (hydroxypyl Methyl nke dị mkpụmkpụ) Ọ nwere ezigbo mmiri sonyere na akụrụngwa na-akpụ akpụ ihe nkiri, ma nwee ọnọdụ maka ịkwadebe fim na-agbanye mmiri.

1.2 Hydroxypyl Methylcellose

Hydroxypyl Methyl Cellulose (hydroxypylthyl methyl nke mkpụmkpụ) site na cellulose, mgbanwe nke ngbanwe, mmeghachi omume na sautralization na ịsacha na nhicha. Mmiri na-agbanye mmiri cellulose [21]. Hydroxypyl Methylcellose nwere njirimara ndị a:

(1) isi mmalite na ebe ndị na-eme ka mgbanwe dị ukwuu. Ihe akụrụngwa nke hydropopyythylthylthylcelllose bụ cellulose eke dị iche iche n'ụwa, nke nwere ihe ndị na-eme ka ọhụrụ.

(2) gburugburu ebe obibi na-enwe mmekọahụ na biodegradable. Hydroxypyl Methylcellose abụghị ihe na-adịghị egbu egbu na enweghị mmerụ ahụ mmadụ ma enwere ike iji ọgwụ na ndị ọrụ nri.

(3) Nnukwu ojiji. Dịka polymer-solullithylthylthylthylthyl methylcellose nwere ezigbo mmiri sos, ma nwee mmiri, kemịkalụ, kemịkalụ na eletriki na eletriki na igwe eletriki na eletriki [21].

1.2.1 ỌRSR SYDYPPPPPRYLYLYLYLILLY

A na - enweta HPMC site na Cellulose mgbe alkalizations, na akụkụ nke polyhydroxyddyyyl eatherypypyl na methyl na propylene oxide na methyl chloride. Ogologo oge HPMC Methy Methy Ranges site na 1.0 ruo 2.0, na hydroxyppropyl ogo nbanye dị na 0.1 ruo 1.0. A na-egosi usoro molecula ya na ọgụgụ 1.1 [22]

N'ihi njikọta hydrogen dị n'etiti cellomolecules macromolecules eke, o siri ike igbari na mmiri. A na-ewebata sọlị na mmiri na mmiri na-aga n'ihu na mbara igwe na-eme ka eriri dị iche iche, nke na-emebi eriri hydrogen n'etiti mkpali [23]]. Hydroxypylthylthylthylthylcelllose (HPMC) bụ ihe eji eme ihe ejikọtara ọnụ, a na-eme ihe eji eme ya, na-enweghị atụ na-atụgharị uche na-enweghị atụ bụ ngosipụta zuru oke nke nhazi Onyinye nke otu obula. - [OCH2CH (CH3)] otu hydroxy na njedebe nke nho, nke nwere ike ịbụ ndị na-arụ ọrụ, nke nwere ike ịbụ ndị na-arụ ọrụ, nke nwere ike ịmịcha, nke nwere mmetụta ụfọdụ n'ime macromolecular yinye; -Zoch3 bụ otu egwuregwu na-enweghị ike, a ga-ahụta saịtị mmeghachi omume mgbe nnọchibido, ọ bụ ihe dị mkpụmkpụ hydrophobic dị mkpirikpi [21]. Ndị otu Hydroxy dị na ngalaba agbakwunyere ọhụrụ na ndị otu hydroxy na-fọdụrụ na mpaghara glucose nwere ike gbanwee site na ndị dị n'elu, na-ebute ihe owuwu dị mgbagwoju anya na akụrụngwa dị iche iche na-agbanwe agbanwe [24].

1.2.2 Mmiri nke Hydropylthylylthyl

Hydroxypyl Methylcelllose nwere ọtụtụ ọmarịcha ihe n'ihi nhazi ya pụrụ iche, nke kachasị mma nke so na mmiri ya. Ọ na-awụga ya na ngwọta colloidal na mmiri oyi, ma ihe ngwọta nwere ụfọdụ ọrụ, nghọta dị elu na arụmọrụ kwụrụ ụgwọ [21]. Hydroxypyl Methylcellose bụ n'ezie mkpụrụ osisi celllise na-agbanwe site na ndagwurugwu mmiri na-ekpo ọkụ na nke methylose na-ekpo ọkụ [21], na mmiri na-eme ka mmiri dị mma. Ọ dị mkpa ka etinye methy cellulose na 0 ruo 5 Celsius C ruo nkeji iri abụọ ruo 40 iji nweta azịza ngwaahịa na nghọta dị mma na viscosity nke [25]. Ngwọta nke ngwaahịa HyDroxypyl Othylcellse naanị na ọ dị na 20-25 Celsius C iji nweta ezigbo nkwụsi ike na nghọta dị mma [25]. Iji maa atụ, a na-emerịrị hydroxylthylthylthylthylthylthylcelllose (granular hone 0,5 mm) nwere ike gbazee na mmiri na-enweghị nsogbu nke 4000 os na 20 Celsius C.

Ngwongwo 1.2.3 Njirimara nke Hydroxypypylthylcelllose

Nchịkọta HyDoxypyl Methylcellse nwere ezigbo ihe ngụkọta mkpụrụ nke edoziri, nke nwere ike inye ezigbo ọnọdụ maka mkpuchi nke ọgwụ na-ahụ maka ọgwụ. Ihe nkiri mkpuchi ahụ na-acha, na-enweghị agba, enweghị isi, siri ike na ụzọ [21].

Yan Yanzhong [26] jiri ule Orthogonal iji nyochaa ihe nkiri na-akpụ akpụ nke ihe nkiri nke hydropyylthylthyl. Inyocha nyocha a rụrụ na ọkwa atọ nwere ụzọ dị iche iche na ihe mgbazi dị iche iche dịka ihe. Nsonaazụ gosiri na ịgbakwunye 10% hydropyylthylthyl na 50% ethanol nwere ihe ndị kachasị mma na-akpụ akpụ, enwere ike iji ihe nkiri na-eme ihe nkiri maka fim ọgwụ ọjọọ.

1.1 Mgbanwe rọrọ nke Plabization nke Hydypypyl Methylcelllose fim

Dịka ihe mmeghari ohuru nke sitere n'okike, ihe nkiri a kwadebere dị ka ihe akụrụngwa nwere ezigbo nkwụsi ike na usoro, ma tufuo ya, nke na-adịghị emerụ ahụ gburugburu ebe obibi. Agbanyeghị, filts cellulose enweghị oke ike, na cellulose nwere ike kpụrụ kpụrụ ma gbanwee.

[27] na-eji Triethyyyyyyyyl Tetrabutyl Chovate na rọba na refludose acetate propionate. Nsonaazụ ahụ gosiri na elongation na ezumike nke cellulose na-abawanye site na 36% na 50% na Acetyl Tetrabutyl dị 10%.

Luo qauslu et 28] a gụrụ ihe fọdụrụnụ glycer, stacose acid na glucose na akụrụngwa nke methylcelllose membranes. Nsonaazụ ahụ gosiri na ogologo oge nke Methyl Cellulose dị mma mgbe mgbakwunye nke methy, na ebili mmiri nke glucose bụ 0,5%.

Glycerlol bụ enweghị agba na-enweghị agba, dị ụtọ, doo anya, viscous na-ekpo ọkụ na-ekpo ọkụ, a na-akpọkarị Glycerin. Kwesịrị ekwesị maka nyocha nke ihe ngwọta, ndị na-adịghị ọcha, fọdụrụnụ, wdg. Sorbillol, hygroscopic ntụ ntụ ma ọ bụ kristal ntụ ntụ, frakes ma ọ bụ nkọcha. O nwere ọrụ nke nnabata mmiri na njide mmiri. Na-agbakwunye ntakịrị na mmepụta nke chiiz na swiiti nwere ike idobe nri dị nro, meziwanye nzukọ ma belata ike nke ájá. Glycerlol na sorbil bụ ihe mmiri mmiri, nke a ga-agwakọta ya na mmiri mkpụrụ osisi mkpụrụ osisi (23]. Enwere ike iji ha dị ka fọdụrụnụ maka cellulose. Mgbe ị na-agbakwunye, ha nwere ike imeziwanye mgbanwe na ịlanarị na ezumike nke fillose fim. 29] N'ozuzu, ịta nke ihe ngwọta bụ 2-5%, na ọnụọgụ plastizer bụ 10-20% nke cellulose ether 10. Ọ bụrụ na ọdịnaya plastizer dị oke elu, ihe na-adịghị mma na colnomenon nke colloid mmiri ga-eme na oke okpomọkụ [30].

1.2 Mgbanwe Crosslinking nke Hydyypropyl Methylcellose fim

Ihe nkiri mmiri ahụ nwere mmiri mmiri nwere ezigbo mmiri soldọn, mana anaghị atụ anya ka ịgba ọsọ ọsọ mgbe ejiri akpa nkwakọ ngwaahịa. Mkpụrụ ndị a na-eji ihe nkiri na-eme ka mmiri ghara ịmị mkpụrụ, nke nwere ike ime ka oke ala ahụ dị larịị nke mkpụrụ. N'oge a, iji chebe osisi, a naghị atụ anya na ihe nkiri ga-ebu ụzọ kpọọ ụfọdụ mmiri na-echebe na mkpụrụ. Ya mere, ọ dị mkpa iji mee ka mmiri mmiri sie mmiri. [21].

Ihe kpatara hydropopylthylthylthylthylthylthyl nwere ezigbo mmiri sollity di iche iche na ndi otu a hydroxyl ka ime ka ha nwenyere hydroxyli na hydropyl Methylcellops na-ebelata, si ya Na-ebelata mmiri na-egbochi mmiri hydyyplopyl methylcellopse, na njikọta nke na-ejikọ ọnụ na ngalaba hydroxy ga-ewelite akụrụngwa akụrụngwa nke fim ahụ ruo oge ụfọdụ. Njikọ Aldehydes na Hydropyylthylthylthylthylthylthylthylthylthyl na glycral, mmeghachi omume abụọ dị ngwa, na glutaraldehyde bụ ihe na-egbu egbu. Ọ dịtụ mma, yabụ na glutaldehyde a na-achupụ maka ndị na-akwado ya. Ọnụ ego ụdị ụdị a na-ejide onwe ya na ihe ngwọta bụ ihe a na-eme bụ 7 ruo 10% nke ibu nke ether. Ọgwụgwọ ọgwụgwọ dị ihe dị ka 0 ruo 30 Celsius C, na oge bụ 1 ~ 120 nkeji [31]. Mmeghachi omume na-edozi ahụ chọrọ ka a rụọ ọrụ n'okpuru ọnọdụ acidic. Nke mbu, aciaganic siri ike na osisi orgaxylic acid na-agbakwunye na ngwọta iji mezie ihe ahụ ihe dị ka 4-6, mgbe ahụ, a na-agbakwunye mmeghachi omume na-ejikọ [32]. Acid eji acid na-etinye HCL, H2SO4, acetic acid, citric acid, na ihe ndị ahụ. Enwere ike ịgbakwunye acid na Aldehyde n'otu oge iji mee ka ihe ngwọta na-ebu mmeghachi omume na-enweghị njikọ na PH dị mkpa nke Ph 33].

Njirimara Njirimara 1.3 nke ihe nkiri hydroxypypylth

Hydroxypylthylthylcelllose bara ọgaranya bara ụba na akụrụngwa, dị mfe iji ihe nkiri, ma nwee mmetụta dị mma. Dịka ihe nchekwa nri, o nwere nnukwu mmepe mmepe [34-36].

Zhuang Rongyu [37] jiri hydropyl ihe nkiri ememme (HPMC) ememme ihe nkiri, wee chekwaa ya na 20 Celsius C ruo ụbọchị iri na asatọ iji mụọ mmetụta ya na Firstness na agba. Nsonaazụ gosipụtara na isi ike nke tomato na HPMC Coatting dị elu karịa nke na-enweghị mkpuchi. A gosipụtakwara ya na HPMC Edinable ihe nkiri nwere ike igbu oge mgbanwe nke tomato sitere na pink ruo na-acha ọbara ọbara mgbe echekwara na 20 ℃.

[38] Nrụpụta nke hydypropyl na-eme ọgwụgwọ na-eme ka usoro ọgwụgwọ, HPMC) na njiri mara mma, Anthocyanin Sonsonidesis nke "WUZOXD" Bayberry Mkpụrụ n'oge nchekwa oyi. Nsonaazụ gosiri na arụmọrụ mgbochi nke bayberry na-eme ka ọ dị mma na HPMC ihe nkiri n'oge a belatara, na mmetụta nke ihe nkiri 5% nke ihe nkiri 5% kachasị mma.

Wang Kaikai et al. [39] ji "Ruzhong Mkpụrụ dị ka ihe nnwale ahụ iji mụọ mmetụta hydycellviin (HPMC) na-ekpuchi na njiri mara na njiri mara nke postharvest bayberry mkpụrụ n'oge nchekwa na 1 ℃. mmetụta nke ọrụ. Nsonaazụ ahụ gosiri na mkpụrụ osisi nke osisi HPMC-Corated Bayberry dị irè karịa otu osisi bara uru, na -ebelata ọnụego ndị na-emebi emebi n'oge nchekwa, si otú ahụ na-adị ogologo oge nchekwa mkpụrụ osisi ahụ.

N'afọ ndị na-adịbeghị anya, ndị mmadụ nwere ihe ndị dị elu ma dị elu maka nchekwa nri. Ndị na-eme nchọpụta n'ụlọ na mba ọzọ gbanwere nyocha ha na-elekwasị anya n'ihe mgbakwunye nri na nkwakọ ngwaahịa. Site na ịgbakwunye ma ọ bụ fesa antioxidants n'ime ihe oriri, ha nwere ike belata iberibe nri. Ọnụ ọgụgụ na-emebi emebi [40]. Antioxidings antioxidants sitere na-enwe nchegbu na-echegbu onwe ha n'ihi nchekwa nchekwa ha dị elu na ezi ahụike na ahụ ike mmadụ [40,41].

Antioxidant nke achara (abbo maka mkpụmkpụ) bụ antioxidant sitere na anụ ahụ pụrụ iche nwere akpa behamboo isi na ezigbo mmiri. Edepụtala ya na National Standard GB2760 na ozi ahụike na-akwado ya dịka ọgwụ mgbochi maka nri anụ ahụ. Enwere ike iji ya dị ka nri nri maka ngwaahịa anụ, ngwaahịa aquatic na nri siri ike [42].

Anyanwụ Lina wdg. [42] Nyochaa isi ihe ndị bụ isi na akụrụngwa nke ngwo akwukwo na-adịkarị ma webata ngwa nke achara abata achara antioxidants na nri. Dinggbakwunye 0.03% AIB na New Mayonezi, mmetụta antioxidant bụ ihe kachasị pụtara ìhè n'oge a. E jiri ya tụnyere otu ego poioxidants poaxidants, mmetụta ọgwụ ya doro anya na ọ dị mma karịa nke tii potephenols; Dinggbakwunye 150% ka biya na mg / l, Njirimara antioxidant na nchekwa nke biya na-abawanye, biya na-abawanye na ahụ mmanya. Mgbe ị na-ejide ogo ahụ mbụ nke ahụ mmanya, ọ na-emekwa ka ntụ ọka na-atọ ụtọ nke achara na-ahapụ [43].

Na nchịkọta, hydroxypropyythylthylcelllose nwere ezigbo usoro ihe nkiri na arụmọrụ dị mma. Ọ bụkwa ihe ndị na-acha akwụkwọ ndụ akwụkwọ ndụ na nke na-emebi emebi, nke enwere ike iji ya dị ka ihe nkiri na nkwakọba ihe n'ọhịa nkwakọ [44-48]. Glycerlol na sornol bụ mmiri abụọ na-amị mmiri. Na-agbakwunye glyceol ma ọ bụ sornol na mkpụrụ osisi cellulose nwere ike ime ka ihe siri ike nke ihe nkiri hydyyplopl methylcellopse, si otú ahụ na-abawanye mgbe ị na-eme ihe nkiri [49-51]. Glutardehyde bụ ihe na-ejikarị ọgwụ ọjọọ eme ihe. E jiri ya tụnyere ndị ọzọ, ọ bụ dị nchebe, ma nwee ndị otu Diagehyde na molekule, na ọsọ na-enweghị njikọ ngwa ngwa. Enwere ike iji ya mee ihe dị ka ngbanwe na-ejikọta nke ihe nkiri hydyplopyl methylcellose. Ọ nwere ike idozigharị mmiri na-egbochi mmiri nke fim ahụ, nke mere na enwere ike iji ihe nkiri ahụ n'ọtụtụ oge [52-55]. Dinggbakwunye achara antixidants na hydroxylithyl methylcellose iji melite ihe ngosi antioxidant nke ihe nkiri na-egbu egbu ma gbasaa ngwa ya na nkwakọ ngwaahịa.

Ndenye 1.4 nke isiokwu

Site na ọnọdụ nyocha dị ugbu a, ihe nkiri-soluble mmiri na-abụkarị nke FVA filts, ndị mmadụ, ihe nkiri mmiri na nke protein na protein. Dịka ihe dabeere na mmanụ, PVA na ndị mmadụ bụ akụrụngwa na-enweghị ike, yana mmepụta usoro nke akụrụngwa ha nwere ike imetọ. Ọ bụ ezie na United States, Japan na mba ndị ọzọ edepụtala ya dị ka ihe na-abụghị ihe na-adịghị mma, nchekwa ya ka na-emeghe ajụjụ. Ma imi na ingesting na-emerụ ahụ mmadụ [8], enweghị ike ịkpọ ya nke ọma na-acha akwụkwọ ndụ akwụkwọ ndụ zuru ezu. Usoro mmepụta nke mmiri na-emepụta mmiri na nke protein na protein na protein na-adịghị mma na ngwaahịa ahụ dị nchebe, mana ha nwere ọghọm nke usoro ihe nkiri ahụ siri ike, ogologo oge, na nsogbu dị mfe. Ya mere, n'ọtụtụ oge, ha kwesịrị ịdị njikere site na iji ihe ndị ọzọ dị ka PVA. Uru eji eme ihe adighi elu. Ya mere, ọ dị mkpa iji zụlite ọhụụ, mmeghari ihe nkiri na-emeghari, mmiri na-egbochi arụmọrụ dị mma iji meziwanye ntụpọ nke ihe nkiri nke ihe nkiri mmiri dị ugbu a.

Hydroxypylthlthylthylcelllose bụ ihe okike polymer, nke na-abaghị uru na akụrụngwa, kamakwa na-eme ka ọ bụrụ ọhụụ. Ọ nwere ezigbo mmiri sonyere na akụrụngwa na-akpụ akpụ ihe nkiri, ma nwee ọnọdụ maka ịkwadebe fim na-agbanye mmiri. Ya mere, akwụkwọ a bu n'obi ịkwadebe ụdị ihe nkiri na-egbochi ọhụrụ dị ka akụrụngwa, ma tinye usoro nkwadebe ya (Glyceol na sotrol). ), a na-ahụ maka njikọta (glutaldehyde), Antioxidant (bamboo akwukwo ihe na-eme ka ihe ha na-eme, iji kwadebe ihe na-arụ ọrụ na akụrụngwa, akụrụngwa na akụrụngwa antioxidant. Ihe nkiri methylcellose mmiri na-agbanye mmiri dị ezigbo mkpa maka ngwa ya dị ka ihe nkiri ihe nkiri na-agbanye mmiri.

1.5 nyocha ọdịnaya

Ihe nyocha a bụ ndị a:

1) A kwadebere ihe nkiri ngwugwu HPMC - nke na-egbochi ihe nkiri na-emepụta ihe nkiri, yana akụrụngwa nke fim-na-eme ihe nkiri nke mmiri hpmc na-eme ihe nkiri nke fim Hpmc mmiri.

2) Iji mụọ mmetụta nke glycerlol fọdụrụ na akụrụngwa akụrụngwa, mmiri na ngwa ọdịnala nke fim mmiri hpmc.

3) Iji mụọ mmetụta nke glutalaldehyde cross na-agagharị na mmiri, akụrụngwa akụrụngwa na ngwa ọdịnala nke fim mmiri HPMC.

4) Nkwadebe nke AOB / HPMC Mmiri Mmiri Mmiri Ọgwụ. Examition na-eguzogide, sọlị mmiri, akụrụngwa arụmọrụ na ngwa ọdịnala nke AOB / HPMC dị mkpa a na-amụ.

Isi nke 2 na Njirimara nke Hydyypyl Methyl Methyl Cellulose Mmiri Ngwugwu

2.1 Okwu mmeghe

Hydroxypylthyththth methylcellose bụ sellulose derivative. Ọ bụ ihe na-adịghị egbu egbu, na-enweghị mmetọ, mmeghari ohuru, ma nwee ezigbo mmiri solbality na ihe na-akpụ akpụ ihe nkiri. Ọ bụ ihe nkiri ihe nkiri nwere ike ịmịcha mmiri.

Isiakwụkwọ a ga-eji hydroxylthylthylthylthylthylthyl methylcellose dị ka ihe nkiri na-eme na-akpata 2%, na-akwadebe ihe nkiri na-eme ka mmiri na-eme ihe nkiri na ihe nkiri na ihe nkiri, ngwaike, yana ihe ndị na-edozi ahụ. Ngwongwo kristal nke X-ray mara ihe nkiri, na ike nguzobe, Elongation na Hazdlellopy mmiri na-egbochi ihe ngosi nke tensylypyl.

2.2 Ngalaba Ngalaba

2.2.1 ihe nlere na ngwa

2.2.2 Nkwadebe ụdị

1) Icheta: tulee ego nke hydropyylthylthylthylthyl na-ekwu okwu elektrọnik.

2) Nghapu: Tinye ihe atụ ahụ dị mkpa na mmiri e debere, ma hapụ ya kpam kpam, wee mee ka ọ nọrọ ụfọdụ oge. mmiri membrane. Edebere na 2%, 3%, 4%, 5% na 6%.

3) Usoro ihe nkiri: - Nkwadebe nke fim nwere ụdị ihe nkiri dị iche iche: tụgharịa ihe nkiri dị iche iche nke ihe nkiri dị iche iche na 40 ~ 50 Celsius na fim fils. Ihe nkiri na-egbochi mmiri na-agbanye mmiri na-agbanye mmiri na ọkpụrụkpụ 25-50 μ nke a na-apụ apụ ma tinye ya na igbe nkụ maka iji ya. A na-eme ihe nkiri dị iche iche na ụdị fim dị iche iche (okpomoku dị iche iche na-acha odo odo na-acha odo odo na-acha odo odo na-acha odo odo. Ihe nkiri na-eme mmiri na-agbanye mmiri na-egbochi iri anọ na asatọ, a na-ehicha ihe nkiri ahụ, ma tinye ya na igbe nkụ maka iji ya. A na-akpọ Sydypypyl Methylcellose mmiri na-egbochi ihe nkiri HPMC maka mkpụmkpụ.

2.2.3 Nchọpụta na nha arụmọrụ

2.2.3.1 Ngụkọta-swiction X-ray (XD)

A na-enyocha oghere nke X-ray (xrd) na-enyocha kristal ọnọdụ nke ihe na-aga. A na-eji ụdị X-ray dị iche nke ARL / XRA na-emepụta nke ụlọ ọrụ themo na Switzerland maka mkpebi ahụ. Ọnọdụ nha: Isi iyi nke X-ray bụ akara Cu-Kα (40kV, 40A). Akụkụ nyocha ahụ sitere na 0 Celsius ruo 80 Celsius (2θ). Scanning ọsọ 6 Celsius / min.

2.2.3.2 Njirimara Njirimara

A na-eji ike tensile na ezumike nke ihe nkiri a dị ka njirisi nke ihe nkiri ahụ dị ka ihe nkiri ya, ike tensirity (ike na-eme ka ọ dị elu na-eme ka ọ dị mma mgbe ihe nkiri ahụ na-eme ka ọ dị na MIPA. Elongation na ezumike (imebi elongation) na-ezo aka na mbara ala mgbe etiwaara ihe nkiri ahụ na mbụ, kwupụtara na%. Iji Incon Incon (5943) Igwe eletriki Igwe eletriki (Shamghai) akụrụngwa nke ihe nkiri na-acha uhie uhie, họrọ samples na elu dị ọcha na-enweghị adịghị ọcha.

2.2.3.3 Njirimara

Ngwongwo ngwa ngwa bu ihe ngosi di nkpa nke ihe nkiri ngwugwu, tumadi tinyere ntughari na haze nke ihe nkiri. Ejiri transmittive na haze nke fim a na-eji Transmittance Haze. Họrọ ihe nlereanya ule na elu dị ọcha na enweghị ihe ọ creụ, jiri nwayọọ tinye ya na ihuenyo ahụ, mezie ya na iko ihe nkiri ahụ na ụlọ (25 Celsius C na 50% Rh). A nwalere ihe nlele ahụ ugboro atọ na uru ego.

2.2.3.4 Mmiri

Bee ihe nkiri 30mm × 30mm na ọkpụrụkpụ dị ihe dị ka 45μm, tinye 100ml mmiri ruo na etiti mmiri ahụ, ma tụọ oge ihe nkiri ahụ kpamkpam [56]. A tụrụ ihe ọ bụla atụ ugboro atọ na a na-ewere ya, yana ngalaba ahụ bụ min.

2.2.4 Nhazi data

Ejirila sọftụ software rụọ ọrụ.

Nsonaazụ na mkparịta ụka

2.3.1 xrd usoro nke HPMC nke fim na-eme ihe nkiri dị iche iche na-akpụ akpụ

Fig.2.1 XRD nke fim HPMC n'okpuru ọdịnaya dị iche iche nke HP

Mgbasa ozi-sara mbara nke X-ray bụ nyocha nke obere kristal dị na ọkwa molecular. Ọgụgụ 2.1 bụ usoro dị iche iche nke HPMC nke dị mkpa fim ndị dị na ngwọta dị iche iche. E nwere ọnụ ọgụgụ abụọ dị iche iche [57-59] (nke dị nso 9.5 Celsius na 20.4 Celsius) na fim HPMC na ọnụ ọgụgụ HPMC na ọnụ ọgụgụ ahụ. Enwere ike ịhụ ya site na ọnụ ọgụgụ ahụ na mmụba nke hpmc ịta, ọnụ ọgụgụ dị iche iche nke ihe nkiri HPMC gburugburu 9.5 Celsius na 20.4 Celsilo elu. Ma na-esighi ike, ogo molecular nhazi (nhazi usoro) buru ụzọ mụbaa ma belata. Mgbe ịta ahụhụ bụ 5%, nhazi usoro nke ụmụ irighiri HPMC dị mma. Ihe kpatara na ihe a dị n'elu pụrụ iche nwere ike ịbụ na mmụba nke ịta ahụhụ HPMC, ọnụ ọgụgụ nke klọọkụ nuclei na ngwọta nke fim na-abawanye, si otú a na-eme ka ha na-abawanye ụba. Mgbe HPMC ịta karịrị 5%, XRD dị iche iche nke ihe nkiri na-esighi ike. Site na echiche nke usoro molecular, mgbe HPMC itinye uche buru oke ibu, viscitse nke usoro ihe ngwọta ịkwaga ma enweghị ike ịhazi ya n'oge, si otú a na-ebute ogo nke ihe nkiri HPMC belata.

2.3.1.2 Njirimara nke Njirimara nke HPMC Try Fimrs n'okpuru ngwọta usoro ihe nkiri dị iche iche.

A na-eji ike tensile na ezumike nke ihe nkiri ahụ dị ka njirisi maka ị na-ekpe ikpe akụrụngwa ya, ike nguzo na-ezo aka na nrụgide ahụ mgbe ihe nkiri ahụ na-egosi na ọ na-arụ ọrụ plastik kachasị mma. Elongation na ezumike bụ oke nke ịchụpụ na mbụ nke ihe nkiri ahụ na ezumike. Ngosi nke akụrụngwa nke ihe nkiri ahụ nwere ike ikpe akwụkwọ ya na ụfọdụ.

Fig.2.2 Mmetụta ọdịnaya dị iche iche nke HPMC na Njirimara Njirimara nke Ihe nkiri HPMC

Site na fig 2.2, na-agbanwe agbanwe nke Tensile na ezumike nke ihe nkiri HPMC n'okpuru ihe nkiri tensc nke ihe nkiri HPMC mụbara na-ebute ụzọ na-akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ akpụ. Mgbe ihe ngwọta ịta bụ 5%, Njirimara nke ihe nkiri HPMC dị mma. Nke a bụ n'ihi na mgbe ị na-eme ihe nkiri na-adị ala, ihe ngwọta dị ala, esemokwu dị na usoro ihe nkiri ahụ dị ala, yabụ ikike kristal nke ihe nkiri dị ala na ihe ya bụ ogbenye; Mgbe ị na-eme ihe nkiri na-eme ka mmiri mmiri bụ 5%, Njirimara arụ ọrụ na-eru uru kachasị; Dị ka ịta nke mmiri na-emepụta ihe nkiri na-abawanye, nkedo na ngbanwe nke ihe nkiri ahụ nwetara, na-ebute mbelata nke ihe nkiri nke fim HPMC. Ya mere, ịta nke 5% HPMC Solutionzọ ihe nkiri na-akpụ akpụ bụ ihe kachasị mma. Arụmọrụ nke ihe nkiri a nwetara dịkwa mma.

2.3.1.3 Njirimara nke HPMC Tring Firms na-eme ihe nkiri dị iche iche

Na fim, transmitten na haze bụ parameter dị mkpa na-egosi nghọta nke fim ahụ. Ọgụgụ 2.3 na-egosi usoro mgbanwe nke transmittince na haze nke fim HPMC n'okpuru ihe dị iche iche na-eme ihe nkiri. Enwere ike ịhụ ya site na ọnụ ọgụgụ nke na mmụba nke usoro ihe nkiri HPMC na-eji nwayọọ nwayọọ belata, na haze mụbara nke ukwuu site na mmụba nke ịta ihe ngwọta.

Fig.2.3 mmetụta nke ọdịnaya dị iche iche nke HPMC na akụrụngwa ngwa ngwa nke fim HPMC

E nwere isi ihe abụọ: buru ụzọ, site na echiche nke ọnụ ọgụgụ ndị a gbasasịrị, ọnụ ọgụgụ dị ala, ọnụ ọgụgụ ahụ nwere mmetụta kachasị na ngwa ọdịnala nke akwụkwọ [61]. Ya mere, na mmụba nke ịta ihe nkiri HPMC nke HPMC, a na-ebelata ihe nkiri nkiri. The ọkụ ọkụ ọkụ ahụ belatara nke ukwuu, ya na haze mụbara nke ukwuu. Nke abụọ, site na nyocha nke usoro ịme ihe nkiri, ọ nwere ike ịbụ n'ihi na ihe ngwọta nke na-egosipụta ihe nkiri. Mmụba na ihe isi ike nke ịba ụba na-eduga na mbelata nke ire ụtọ nke ihe nkiri ahụ na mbelata nke ngwa ngwa nke ihe nkiri HPMC.

2.3.1.4 mmiri solublition nke hpmc dị mkpa fim dị iche iche na-etolite mmiri

A na-emetụta ngụgụ mmiri nke ihe nkiri mmiri na-emetụta ihe nkiri ha na-ese ihe. Bee ihe nkiri 30mm × 30mm 30mm eji ihe nkiri dị iche iche eme ka ihe nkiri dị iche iche, ma kaa akara ihe nkiri ahụ na "+ iji tụọ oge ihe nkiri ahụ kpamkpam. Ọ bụrụ na ihe nkiri ahụ ma ọ bụ na-arapara na mgbidi nke beaker, na-agbachighị. Ọgụgụ 2.4 bụ eserese na-eme ihe nke ihe nkiri HPMC n'okpuru ụdị mmiri na-eme ihe nkiri. Enwere ike ịhụ ya site na mmụba nke ihe nkiri mmiri mmiri, na-agbanye mmiri oge fim HPMC na-abịa ogologo oge, na-egosi na mmiri sochiri fim HPMC na-ebelata. A na-akọwapụta na ihe kpatara ya nwere ike ịbụ na mmụba nke usoro ihe nkiri HPMC na-abawanye, ike na-eme ka ị na-eme ka ihe nkiri HPMC na mmiri na mbelata.

Fig.2.4 Mmetụta nke HPMC dị iche iche na mmiri nke fim HPMC

2.3.2 Mmetụta nke ihe nkiri na hpmc dị mkpa fim

2.3.2.1 XD usoro nke HPMC Try Firm Firms na ihe nkiri dị iche iche na-eme ụdị okpomọkụ

Fig.5.5 XRD nke fim HPMC n'okpuru ihe nkiri dị iche iche

Ọgụgụ 2.5 na-egosi usoro XDC nke hpmc dị mkpa fim dị iche iche na-akpụ okpomọkụ. Uwe abụọ dị iche iche na 9.5 Celsius na 20.4 Celsius maka ihe nkiri HPMC. Site n'echiche nke oke ugwu nke iche iche, na mmụba nke okpomọkụ nke na-akpụ akpụ nke ọma, ọnụ ọgụgụ dị iche iche dị iche iche na-ebute ike, ike nke ike kristal na-ebutekwa. Mgbe ọnọdụ fim ahụ dị afọ 50 Celsius C, usoro enyere iwu nke molules hpmc, mmụba nke nucShal nuclei pere mpe, na-esi ike kristal siri ike; Dị ka okpomoku na-eto nke ọma na-eto nke ọma, ọnụego nke necleanion na-abawanye, a na-emegharị akwara nke akwara na-adị mfe, ya mere, a na-adị mfe iji klọọkụ dị elu, yabụ na -akpakọ ahụ ga-eru oke uru na ụfọdụ okpomọkụ; Ọ bụrụ na ọnọdụ fim dị oke elu, ngagharị molecular dị oke ike, e guzobere nucleus nukleus siri ike ma ọ na-esiri ike ịkọ kristal [62,63]. Ya mere, mkpu ihe nkiri HPMC na-abawanye mbụ wee belata na mmụba nke ihe nkiri na-etolite okpomọkụ.

2.3.2.2 Njirimara Ngwongwo HPMC Tring Firms na ihe nkiri dị iche iche na-eme ụdị okpomọkụ

Mgbanwe nke ihe nkiri ahụ na-etolite okpomọkụ ga-enwe usoro ụfọdụ na akụrụngwa arụ ọrụ nke fim ahụ. Ọgụgụ 2.6 na-egosi usoro mgbanwe nke ike tensile ike na oge ezumike nke fim HPMC na ụdị fim dị iche iche na-akpụ ụdị okpomọkụ. N'otu oge ahụ, o gosipụtara omume nke ịba ụba wee belata. Mgbe ihe nkiri ahụ na-akpụpụta okpomọkụ bụ 50 Celsius C, ike tensile na oge ezumike ahụ ruru ụkpụrụ HPMC rute ụkpụrụ dị oke, nke dị 116 na 32%, n'otu n'otu.

Fig.2.6 Mmetụta ihe nkiri na-akpụpụta okpomọkụ na ngwa ọrụ nke fim HPMC

Site n'echiche nke usoro molequalar, ka ukwuu nhazi nke ụmụ irighiri ihe, ka mma ike tensile [64]. Site fig. Mgbe ihe nkiri a na-eme ihe nkiri bụ 50 Celsius C, ogo nke usoro ihe nkiri HPMC na-ebu ụzọ na-abawanye na mmụba nke ihe nkiri, yana oke ọnụ ahịa na-egosi na ihe nkiri na-etolite okpomọkụ nke 50 ℃. Elongation na ezumike na-egosi ihe na-eme ka mmadụ buru ụzọ na-aghọrọ mbụ wee belata. Ihe kpatara ya nwere ike ịbụ na mmụba nke oke okpomọkụ, usoro n'usoro nke moleculu na-ebu ụzọ abawanye na ebe a na-agbasa polymer matriks nke polymer. Na matrix, a na-akpụpụta ihe owuwu anụ ahụ, nke na-arụ ọrụ ụfọdụ na akuku aka nri [65]

2.3.2.3 Njirimara nke fim HPMC na ihe nkiri dị iche iche na-eme ka okpomọkụ

Ọgụgụ 2.7 bụ mgbanwe na-eji ngwa anya nke ihe nkiri HPMC na ihe nkiri dị iche iche na-akpụ okpomọkụ. Enwere ike ịhụ ya site na ọnụ ọgụgụ nke na mmụba nke ihe nkiri na-etolite okpomoku, transminance nke ihe nkiri HPMC na-abawanye, Njirimara ihe nkiri HPMC na-akacha mma.

Fig.7.7 Mmetụta ihe nkiri na-akpụzi ọnọdụ okpomọkụ na akụrụngwa nke hpmc

Dabere na mmetụta nke ọnọdụ okpomọkụ na moleculu ahụ dị na ihe nkiri [66], mgbe okpomọkụ mmiri dị na hpmc n'ụdị mmiri ga-agbanwe, na HPMC dị na ọnọdụ iko. Voyotilization nke ihe nkiri ahụ na hpmc, wee kpụchaa ịgbasasị na oghere ndị ahụ mgbe ọ na-eme ihe nkiri ahụ dị ala na oghere dị elu; Dị ka ọnọdụ okpomọkụ na-abawanye, akụkụ molular nke Hpmc na-amalite ịkwaga, oghere ndị ahụ na-agbasasị, na mbugharị ọkụ na-abawanye [68]

2.3.2.4 Mmiri Slublition nke fim HPMC na ihe nkiri dị iche iche na-akpụ ụdị okpomọkụ

Ọgụgụ 2.8 na-egosi ụzọ sọsọ mmiri nke fim HPMC na ihe nkiri dị iche iche na-eme ụdị okpomọkụ. Enwere ike ịhụ ya site na ọnụ ọgụgụ na-eme ka oge fim HPMC na-abawanye na mmụba nke fim, ya bụ, mmiri na-agbaze mmiri fim Hpmc na-akawanye njọ. Na mmụba nke ụdị fim na-etolite, ọnụego mmiri mmiri na ọnụego Gevecular na-ebelata, na-eme ka ọ sie ike maka molecules mmiri ka ịbanye n'etiti ụmụ irighiri mmiri Hpmc. A na-ebelata sossible mmiri.

Fig.2.8 Mmetụta ihe nkiri na-akpụpụta okpomọkụ na mmiri nke ihe nkiri HPMC

2.4 nchịkọta nke isiakwụkwọ a

N'isiakwụkwọ a, eji Hydroxyythythythylthylthythlcelllose mee ihe iji dozie fim HPMC nke na-agbanye mmiri na-agbanye usoro ihe nkiri HPMC. Nnọkọ nke XRD na-enyocha mkpu ihe nkiri HPMC; A nwalere ihe nkiri eji arụ ọrụ HPMC na-enyocha ma nyochaa igwe na-anwale igwe na-anwale, na ngwa ngwa nke ihe nkiri HPMC site na onye na-ebugharị ọkụ. A na-eji oge mgbọrọgwụ na mmiri (oge ịrọ mmiri) iji nyochaa mmiri ya. A na-enweta nkwubi okwu ndị a site na nyocha ndị a dị n'elu:

1) Njirimara nke ihe nkiri HPMC buru ụzọ mụbaa ma belata mmụba nke ịta ihe ngwọta, na mbụ mụbara wee belata na mmụba nke ụdị fim ahụ. Mgbe ịta nke usoro ihe nkiri HPMC bụ 5% na ụdị Fim-na-etolite nke Film bụ 50 Celsius C, Njirimara arụ ọrụ nke ihe nkiri ahụ dị mma. N'oge a, ike tensile dị ihe dị ka 116MPA, na mbara ntoju na ezumike bụ ihe dị ka 31%;

2. na-echebara echiche nke usoro ihe nkiri a ga - agafe agafe 5%, na ụdị fim ahụ ekwesịghị gafere 50 Celsius C

3) Mmiri na-esochi ihe nkiri HPMC gosipụtara ọnọdụ dị ala na mmụba nke ịta nke usoro ihe nkiri na-etolite na mmụba nke ụdị fim ahụ. Mgbe ịta ihe nkiri 5% nke 5% nke 5% nke mkpụrụ osisi 5% nke 50 Celsius Cy, mmiri ahụ na-agbaze oge ihe nkiri ahụ bụ 55 min.

ISI NKE ISI NIILE NA-EGO NA HPMC MGBE NKE NIILE

3.1 Okwu mmeghe

Dị ka ụdị ihe nkiri polymer nke polymer hpmc mmiri na-agbanye mmiri nwere atụmanya mmepe. Hydroxypylthyththth methylcellose bụ sellulose derivative. Ọ bụ ihe na-adịghị egbu egbu, na-adịghị emetọ, na-emeghari, kemịkasị, ma nwee ezigbo ihe. Mmiri na-agba mmiri na ihe nkiri, ọ bụ ihe nkiri na-enye ihe nkiri na-egbochi.

Isiakwụkwọ gara aga tụlere nkwadebe mmiri nke ihe nkiri HPMC - soskpalite mmiri na-emepụta ihe nkiri, na nsonaazụ nke ihe nkiri na-akpụ akpụ nke na-eme ihe nkiri na-emepụta ihe nkiri mmiri. Mmetụta arụmọrụ. Nsonaazụ gosiri na ike tensile nke fim ahụ bụ ihe dị ka 116MPA na mbara ala bụ 31% n'okpuru ọnọdụ kachasị na ọnọdụ ịta. Ihe siri ike nke fim ndị dị otú ahụ adịghị njọ na ụfọdụ ngwa ma chọrọ ndoziwanye ọzọ.

N'isiakwụkwọ a, a na-eji Hydroxylithythylthylththylcelllose ka na-eji akụrụngwa, a na-akwadebe ihe nkiri ngwugwu mmiri site na ngwọta nkedo nke ọma. , Elongation na ezumike), Njirimara ngwa ọdịnala (transmibttance, haze) na mmiri.

3.2 Ngalaba Uche

3.2.1 ihe nlere na ngwa

Isiokwu 3.1 nnwale na nkọwapụta

Isiokwu nyocha nke 3.2 na nkọwapụta

3.2.2 Ndokwadebe nlele

1) Weighing: Weigh a certain amount of hydroxypropyl methylcellulose (5%) and sorbitol (0.05%, 0.15%, 0.25%, 0.35%, 0.45%) with an electronic balance, and use a syringe to measure glycerol Alcohol (0.05%, 0.15%, 0.25%, 0.35%, 0.45%).

2) Nghapu: Tinye hydypylthylthylthylthylthylthylthylthylthylylthylthyl na mmiri a kwadebere, wee tinye glyceol ma ọ bụ sorbil na nkebi dị iche iche. Na hydroxypylthylthylthyl methylcelllose ngwọta, mee ka ọ gwakọta ya nke ọma, hapụ ya ka ọ bụrụ 5 nkeji (izo ya) iji nweta ụfọdụ mmiri nke mmiri na-eme ihe nkiri.

3) Ihe nkiri a na-eme: gbanye mmiri a na-emepụta ihe nkiri n'ime iko Petri ma tinye ya ruo oge iji mee ka ọ bụrụ nke akọrọ ma mepụta ihe nkiri iji mee ihe nkiri na ọkpụrụkpụ nke 45 μm. Mgbe etinyechara ihe nkiri ahụ na igbe nkụ maka iji ya.

3.2.3 njirimara na nnwale arụmọrụ

3.2.3.1 Achịcha ActaredCoopcopy (FT-IR)

Ngosipụta dị iche iche nke a na-emegharị (FTIR) bụ usoro dị ike iji gosipụta ọrụ ọrụ dị na usoro molecular na iji mata otu ọrụ. A na-ejikọ ihe nkiri na-egbochi ihe nkiri HPMC na iji nicolet 5700 transform inframed infromed proviced na-emepụta ihe ngosi. Ejiri usoro ihe nkiri a dị mkpa, nyocha ahụ bụ 500-4000 cm-1, na ọnụ ọgụgụ nlele ahụ bụ 3 maka 24 H maka infraredcycopy.

3.2.3.2 Scess AGGE X-SYX (XD): Otu dị ka 2.2.3.1

3.2.3.3 Mkpebi nke Njirimara Ọrụ

A na-eji ike tensile na oge a na-eme ihe nkiri a dị ka parameters maka ikpe njikwa arụ ọrụ ya. Elongation na ezumike bụ oke nke ịchụpụ na mbụ ogologo mgbe agbajiri fim ahụ, na%. Iji Incon Incon (5943) Mwepụta Eletholic Igwe eletriki Igwe Ntugharị Tenton (Nnwale Nnwale GB13022-92 RSTEPS na-enweghị adịghị ọcha na-enweghị adịghị ọcha.

3.2.3.3.4 Mkpebi nke ngwa ngwa: Otu dị ka 2.2.3.3

3.2.3.5 Mkpebi nke Slublity

3.2.4 Nhazi data

A na-ahazi data nnwale site na Excel, a na-adọta eserese site na eserese site na eserese.

3.3 nsonaazụ na mkparịta ụka

3.3.1 Mmetụta Glycerlol na sornol na ụdị ihe nkiri nke fim HPMC

(a) glycerlol (b) sornol

Fig.3.1 FT-IR nke fim HPMC n'okpuru dị iche iche glyceol ma ọ bụ sornolum

Ngosipụta dị iche iche nke a na-emegharị (FTIR) bụ usoro dị ike iji gosipụta ọrụ ọrụ dị na usoro molecular na iji mata otu ọrụ. Ọgụgụ 3.1 na-egosi ụdị fim HPMC nke ihe nkiri HPMC nwere ihe dị iche iche glyceol na mgbakwunye sornol. Enwere ike ịhụ ya site na ọnụ ọgụgụ nke ihe nkiri mara mma nke ihe nkiri HPMC bụ na mpaghara abụọ ahụ: 2600 ~ 37-59], 3418cm-1

A na-eme ka eriri afọ nke ihe dị nso na-akpata site na nkekọ nke oh, 150cm - 150cm-1 bụ 1657cm - 1 bụ ọnụ ọgụgụ dị elu nke otu hydroxyl. Ọnụ ọgụgụ dị elu nke otu hydroxyl na ịgbatị mkpọda nke Framework, 945cm-1 bụ ọnụ ọgụgụ dị elu nke -ch3 [69]. A na-ekenye ọkwa dị elu na 1454cm-1, 1373CM-1, 1315cm-1 na 945cm-1 na-ekegharị na Asymmetric, na-ebugharị ihe na-efe efe nke-plane, na-eme njem na-agafe agafe-18]. Mgbe ọgba fọdụrụ, ọ bụghị ọnụ ọgụgụ dị iche iche a na-eme ka a na-emepụta ihe nkiri a, na-egosi na Hpmc ahụghị mgbanwe dị mkpa dị mkpa, ya bụ, plastikter ebibighị ihe owuwu ya. Na mgbakwunye nke glycerl, na-agbatị elu na-achawanye elu-3418cm-1 nke ihe nkiri na-etinye aka na 1050cm-1 na-esighi ike, na -atụ ọnụ ọgụgụ dị nta na nke abụọ na sekọndrị na-esighi ike; Na mgbakwunye nke Sornoll gaa na ihe nkiri HPMC, The -Hoh na-agbatị ọnụ ọgụgụ na-acha uhie uhie na 3418cm-1 na-esighi ike, na ọnụ ọgụgụ na-etinye aka na 1657cm-1 na-esighi ike. . A na - eme ka mgbanwe ndị a na - enwekarị ihe na - enweghị atụ na njikọta nke njikọta, nke na - eme ka ha gbanwee na -n -ans na--ch. N'ihi obere, ntinye nke ihe ndị na - egbochi ihe na - egbochi agbụ hydrogen, yabụ ike tensile nke ihe nkiri rọba na-ebelata [70].

3.3.2 mmetụta nke glycerlol na sornol na XD nke fim HPMC

(a) glycerlol (b) sornol

Fig.2 xrd nke fim HPMC n'okpuru dị iche iche Glyceol ma ọ bụ sorbilim

Nchịkọta-sara mbara nke X-ray (XRD) na-enyocha kristal steeti na ọkwa molecular. A na-eji ụdị X-ray dị iche nke ARL / XRA na-emepụta nke ụlọ ọrụ themo na Switzerland maka mkpebi ahụ. Ọgụgụ 3.2 bụ usoro ihe nkiri nke egwuregwu HPMC na mgbakwunye dị iche iche nke glycerlol na sornol. Na mgbakwunye nke glycerlol, ike nke ọnụ ọgụgụ dị iche iche na 9.5 Celsius na 20.4 Celsius ike; Site na mgbakwunye nke sorbil, mgbe mgbakwunye ahụ bụ 0.15%, elu ndị mgbasawanye na 20.4 Celside na 20.4 fim na-adịghị ala ala karịa nke ihe nkiri HPMC na-enweghị sornolc. Na mgbakwunye na-aga n'ihu nke sorbil, ọnụ ọgụgụ dị iche iche na 9.5 Celside ike ọzọ, na elu ndị dị iche na 20.4 Celsius edoghị nke ukwuu. Nke a bụ n'ihi na mgbakwunye nke Glycenlol na sornol na-eme ka nhazi nke ụdọ ma na-emebi ihe owuwu kristal mbụ, si otú a belata mkpu kristal nke fim ahụ. Enwere ike ịhụ ya site na ọnụ ọgụgụ ahụ Glycerol nwere mmetụta dị ukwuu na kristal nke fim HPMC, na-egosi na Glymc na hpmc nwere ezigbo ndakọrịta. Site na nyocha nke na-arụ ọrụ, sornol nwere ihe owuwu sugar nke yiri nke cellulose, na nsonaazụ ya na-adịghị ike, yabụ, ọ nwere obere mmetụta na kristal celltallization.

[48].

3.3.3 Mmetụta Glycerlol na Sornol na Njirimara Njirimara nke Ihe nkiri HPMC

A na-eji ike tensile na ezumike nke ihe nkiri a dị ka parameters ikpechi akụrụngwa ya, yana nha nke Njirimara arụ ọrụ nwere ike ikpe akwụkwọ ya na ụfọdụ. Ọgụgụ 3.3 na-egosi mgbanwe na tenslile ike na oge ezumike nke fim HPMC mgbe ịgbakwunye kpụrụ akpụ.

Fig.3.3 mmetụta nke glycerlol ma ọ bụ sorbiton na akụrụngwa akụrụngwa nke fim HPMC

Enwere ike ịhụ ya site na eserese 3.3 (a) nke ahụ na mgbakwunye nke glyceran fim na mbụ na-ebu ụzọ belata ngwa ngwa, wee na-abawanye nwayọ ma na-abawanye na-agbada. Elongation na oge ihe nkiri HPMC buru ụzọ mụbaa, n'ihi na glyceran nwere ihe ndị a hydrophilic otu, nke na-eme ka ọ bụrụ ihe na-arụ ọrụ hydretion (71], na-eme ka mgbanwe nke fim ahụ. Na mmụba na-aga n'ihu nke glycerol mgbakwunye, elongation na ezumike ihe nkiri HPMC na-ebelata, nke a bụ n'ihi na ihe nkiri dị n'etiti Macromolecular na-enwe nrụgide, site na iwelata ihe nkiri ahụ na ezumike ihe nkiri ahụ. Ihe kpatara mbelata nke Tensile ike bu: Nkwekorita nke obere molecol nke Glycerol na - emebi emebi n'etiti macromolecules, ma belata ike tensile nke fim; The Tensus nwere ike ịbawanye ụba, site na ụzọ nke usoro molecler, glyceol na-abawanye ngbanwe nke polymen molecular agbụ nke polymer molecular ígwè, ma na-eme ka ike tensile nke ihe nkiri na-abawanye ntakịrị; Agbanyeghị, mgbe enwere ike glycel, a na-ahazi ụdị molielar dị ka usoro nhazi nke usoro ihe nkiri ahụ dị elu, na-ebute ike tensile nke ihe nkiri HPMC. Ebe ọ bụ na mmetụta ndị na-akpata isi ike dị na ike tensile nke ihe nkiri HPMC, ego nke Glycer kwukwara na ekwesịghị ịdị ukwuu.

Dị ka egosiri na eserese 3.3 (b), na mgbakwunye nke sorbil, onye na-eme ihe nkiri nke ihe nkiri HPMC buru ụzọ mụbaa ma belata. Mgbe ego nke Sorbitlol bụ 0.15%, mbara ala na-eme ihe nkiri HPMC ruru 45%, mgbe ahụ, mgbe ahụ, mgbe ahụ changation na oge na-achapụta ihe nkiri ahụ belatara ọzọ. Ike tensile mbelata ngwa ngwa, wee rịa ndị mmadụ gburugburu 50MP na mgbakwunye sotrol. Enwere ike ịhụ na mgbe ego nke Sorbil gbakwunyere bụ 0.15%, mmetụta rọkarịrị kachasị mma. Nke a bụ n'ihi na mgbakwunye nke obere morbil na-eme ka usoro oge niile dị iche iche nke ụdọ, na-ebelata ihe na-akpata ihe nkiri ahụ na-abawanye na ike tensile ọdịda. Dika ego nke Sorbil gara n'ihu na-abawanye, elongation na mbelata nke ihe nkiri a, n'ihi na mbelata nke ihe nlere nke Macromolecules nke dị n'etiti Macromolecules na mbelata nke ihe nkiri.

Tụnyere mmetụta kpụ ọkụ n'ọnụ nke Glycencol na fim HPMC, na-agbakwunye 0.15% glycer nwere ike iwepụta oge ihe nkiri ahụ n'ihe dị ka 50%; Mgbe ị na-agbakwunye 0.15% sorbit nwere ike ịbawanye mbara ezumike na ezumike nke ọnụego ahụ ruru ihe dị ka 45%. Ike Tenle be belatara, na mbelata pere mpe mgbe agbakwunyere Glycer. Enwere ike ịhụ ya na mmetụta rọba nke Glycel na fim HPMC dị mma karịa nke sornol.

3.3 Mmetụta Glycerlol na sornol na ngwa ngwa nke fim HPMC

(a) glycerlol (b) sornol

Fig.4.4 mmetụta nke Glycerlol ma ọ bụ ihe nkiri Sorbilion nke fim HPMC

Ndị na-eme mkpọtụ na haze bụ parameter dị mkpa nke nghọta nke ihe nkiri ngwugwu. Visibiliti na idoanya nke ngwongwo ngwugwu kachasị dabere na ntụgharị ọkụ na haze nke fim. Dị ka egosiri na eserese 3.4, mgbakwunye nke Glycerlol na sornol abụọ metụtara ngwa ọdịnala HPMC, ọkachasị aehu. Ọgụgụ 3.4 (a) bụ eserese na-egosi mmetụta nke Glycerol gbakwunye na ngwa ọdịnala nke fim HPMC. Na mgbakwunye nke glycerl, transminance fim na-ebu ụzọ mụbaa ma belata, na-erute uru dị na 0.25%; Haze mụbaa ngwa ngwa wee jiri nwayọ nwayọ. Enwere ike ịhụ ya site na nyocha dị n'elu nke na mgbe mgbakwunye Glycel bụ 0.25%, Njirimara ngwa ọdịnala nke fim ahụ ka mma, yabụ mgbakwunye ego nke Glycer ekwesịghị gafere 0.25%. Ọgụgụ 3.4 (B) bụ eserese na-egosi mmetụta nke mgbakwunye Sornol Tụkwasịrị na ngwa ọdịnala nke fim HPMC. Enwere ike ịhụ ya site na ọnụ ọgụgụ nke na mgbakwunye nke Sorbil, ihe nkiri HPMC na-ebu ụzọ na-ebu ụzọ, wee belata, na mbufe na-abawanye mbụ wee na-abawanye. belatara, na ndọtị ọkụ na haze pụtara na-apụta n'otu oge mgbe ego nke Sornollol dị 0.45%. Enwere ike ịhụ na mgbe ego nke Sorbil kwukwara dị n'etiti 0.35 na 0.45%, akụrụngwa ya ka mma. Iji ihe nkiri HPMC atụnyere nsonaazụ ihe nkiri HPMC, enwere ike ịhụ ya na sornol enweghị mmetụta na ngwa ọdịnala nke fim.

N'ikwu okwu, ihe nwere oke ọkụ ọkụ ga-enwe ala dị ala, na nke ọzọ, mana nke a abụghị mgbe niile. Ụfọdụ ihe nwere transminance na-enwu enwu kamakwa ụkpụrụ haze, dị ka mkpa fim dị ka friowod [73]. Ihe nkiri a kwadebere n'oge nnwale a nwere ike ịhọrọ plastizer kwesịrị ekwesị na mgbakwunye ego dị ka mkpa.

3.3.5 mmetụta nke glycerlol na sornol na mmiri nke fim HPMC

(a) glycerlol (b) sornol

Fig.3.5 Mmetụta nke glycerlol ma ọ bụ sorbitonn mmiri sosc fim hpmc

Ọgụgụ 3.5 na-egosi mmetụta nke glycerlol na sornol na mmiri na-esochi fim fim HPMC. Enwere ike ịhụ ya site na mmụba nke ọdịnaya fọdụrụ, mmiri na-eme ka mmiri na-acha uhie uhie, ya bụ, glycel nwere mmetụta ka ukwuu na mmiri sornol. Ihe kpatara GDDDOXYLYLYLLYLLellose nwere ezigbo mmiri sosblity bụ n'ihi ịdị adị nke ọnụ ọgụgụ dị ukwuu nke ìgwè ndị hydroxy. Site na nyocha nke ụdị a infrared, enwere ike ịhụ na mgbakwunye nke glycerlol, na-egosi na ọnụ ọgụgụ ihe nkiri HPMCY na-ebelata, yabụ na mmiri na-agbada na-ebelata.

3.4 Akụkụ nke a

Site na nyocha arụmọrụ nke ihe nkiri HPMC, enwere ike ịhụ na rọrọ na Clabizer Glycerlol na-eme ka ihe nkiri HPMC na-eme ka ọ dịkwuo elu na ezumike ihe nkiri. Mgbe mgbakwunye nke glycerlol bụ 0.15%, akụrụngwa nke fim HPMC dị mma, ike tensile dị ihe dị ka 60MPA, na mbara igwe na ezumike bụ ihe ruru 50%; Mgbe mgbakwunye nke Glycel bụ 0.25%, Njirimara ngwa ọdịnala dị mma. Mgbe ọdịnaya nke Sorbil bụ 0.15%, ike Tenmc nke ihe nkiri HPMC bụ ihe dị ka 55MPA, na mbara ntopute na ezumike na-abawanye ruo ihe dị ka 45%. Mgbe ọdịnaya Sorbil bụ 0.45%, Njirimara ngwa ọdịnala nke ihe nkiri ahụ ka mma. Ma jọgburu kpụrụ akpụ belatara mmiri sọlị na fim HPMC, ebe Sornotrol enwechaghị mmetụta na mmiri na-eso ụzọ fim HPMC. Tụnyere ntụnyere nke nsonaazụ chara rọba na Njirimara nke ihe nkiri HPMC na-egosi na mmetụta rọba nke Glycel na fim Hpmc dị mma karịa nke Sornollol.

Isi nke 4 mmetụta nke ndị nnọchi anya na-eme ka ihe nkiri HPMC - soluble mmiri

4.1 Okwu mmeghe

Hydroxypyl Methylcellose nwere otutu hydroxy otu na otu hydropopopoxy otu, ya mere, o nwere ezigbo mmiri sossible. Akwụkwọ a na-eji ezigbo mmiri na-agwalite akwụkwọ ndụ akwụkwọ ndụ akwụkwọ ndụ akwụkwọ ndụ na gburugburu ebe obibi na-agbanye gburugburu. A choro na itinye ihe nkiri mmiri, a chọrọ ihe nkiri nke ihe nkiri mmiri na ọtụtụ ngwa, mana oge ụfọdụ na-egbu oge [21].

Ya mere, na isiakwụkwọ a, a na-eji glutaldehyde na-echebe ihe nkiri na-egbochi ihe na-egbochi mmiri mmiri na-egbochi ihe nkiri iji belata mmiri nke ihe nkiri ahụ ma gbuo oge ịlele mmiri. Mmetụta nke mgbakwunye olu glutaldehyde dị iche iche na mmiri, akụrụngwa arụ ọrụ na akụrụngwa na-egosi na-amụ anya.

4.2 Akụkụ nnwale

4.2.1 Ihe nnwale na ngwa

Tebụl 4.1 Ihe Nnyocha na nkọwapụta

4.2.2 Nkwadebe Nkwadebe

1) Uche: tulee ego nke hydropylthylthylthylthylthylthyl methylcellose (5%) na nguzozi elektrọnik;

2) Nghapu: A na-agbakwunye hydypylithythylthylthylthylthylthylthylthym na mmiri na-etinye ya, na-akpali ya ruo oge ụfọdụ (na-eme ka mmiri dị iche iche) enwetara glutaldehyde ego kariri;

3) Ihe nkiri a na-eme ka ihe nkiri ahụ mee mmiri mmiri n'ime iko Petri ma tụnye ihe nkiri a na-akpọ ya, ma tinye ya na igbe na-akpọchi.

4.2.3 njirimara njirimara na nnwale nnwale

4.2.3.1 Achịcha Actarepycopy (FT-IR) nyocha

A na - ekpebi ihe nkiri nke ihe nkiri HPMC na iji nicolet 5700 Infrared spectometer mepụtara ụlọ ọrụ thermolectric na - emepụta ụdị.

4.2.3.2 Sces iche X-ray Difroction (XD) nyocha

Akụkụ-sara mbara nke X-ray dị iche iche (XRD) bụ nyocha nke ọnọdụ kristal nke ihe na-egbu egbu. Na mpempe akwụkwọ a, ọnọdụ Crystal nke ihe nkiri ahụ na-ekpebi iji ARL / Xtra X-ray difceractameter mepụtara site na thermo Arl nke Switzerland. Ọnọdụ nha: Isi iyi nke X-ray bụ Ngwọta Ngwọta Cu-Kα (40 kV, 40 ma). Nyochaa scan si 0 Celsius ruo 80 Celsius (2θ). Scan ọsọ 6 Celsius / min.

4.2.3.3 Mkpebi nke Mkpesa Mmiri: Otu Dị ka 2.2.3.4

4.2.3.4 Mkpebi nke Njirimara Ọrụ

Iji Incon Incon (5943) Mweghachi eletriki Igwe eletriki (Nnwale GB13022-92 RSTEPS CORT PLULS NA EGO NA-EKWU EGO NA-EGO.

4.2.3.5 Mkpebi nke Njirimara Ngwa

Iji TransMintle Stermer Ezo, họrọ ihe nlele ka a nwalere ya na elu dị ọcha, ma tụọ ntụgharị na haze nke ihe nkiri ahụ na ụlọ (25 ° C na 50% Rh).

4.2.4 Nhazi data

Ejiri sọftụwia na-eme nyocha ahụ wee mepụta data nnwale ahụ.

4.3 nsonaazụ na mkparịta ụka

4.3.1 Ntanetị Abroadption nke Glutalaldehyde-Crowled fim HPMC

Fig.4.1 FT-IR nke fim HPMC n'okpuru ọdịnaya Glutaaldehyde dị iche iche

Azụmahụ acrarationcopy bụ ihe siri ike iji mara otu ọrụ dị na usoro molecular na iji mata otu ọrụ. Iji maa mma mgbanwe mgbanwe nke hydyypyl Methylcellose mgbe agbanweela ule, a na-eduzi fim na HPMC fim mbụ tupu mgbe agbanwee. Ọgụgụ 4.1 na-egosi ihe nkiri na-eme fim HPMC na ọnụọgụ dị iche iche nke glutaldehyde, na nrụrụ nke fim hpmc

Ugwu Vibrational nke-na-eme mkpọtụ dị nso 3418cm-1 na 1657cm-1. Na-atụnyere ihe nkiri na-enweghị isi nke fim HPMC, enwere ike ịhụ ya na mgbakwunye nke glutaldehyde, na-egosi na ọnụọgụ nke otu hydroxy na HPMC A na-ebelata Moleculu belata site na mmeghachi omume nke na-ejikọ n'etiti ụfọdụ ìgwè hydroxy na ndị otu Dialdyde na glutardehyde [74]. Na mgbakwunye, achọtara na mgbakwunye nke glutaldehyde agbanwebeghị ogo nke ịdị elu nke HPMC, na-egosi na mgbakwunye nke glutalaldehyde esighị n'otu akụkụ hpmc.

4.3.2 XD usoro nke glutardehyde-cross fim fim hpmc

Site na ịme usoro X-ray na ihe ma na-enyocha usoro dị iche iche, ọ bụ usoro nyocha iji nweta ozi dị ka usoro ma ọ bụ morphology nke atọm n'ime ihe a. Ọgụgụ 4.2 na-egosi usoro ihe nkiri XRC nke fim HPMC nwere mgbakwunye glutaaldehyde dị iche iche. Site na mmụba nke mgbakwunye glutaldehyde, ike nke ọnụ ụzọ dị iche iche nke HPMC gbara ya gburugburu 9.5 Celsius, n'ihi na Aldehydes na molule glutaldehyde molekulde molekule molekulde molekulde molekule molekulde molekulde molekule molekule molekulde molekule molekulde molekule molekule. Ihe mmeghachi omume nke na-edozi ahụ na-eme n'etiti otu hydroxyl na otu hydroxyl na HPMC Molecular, nke na-egbochi ngagharị nke eriri akwara [75], si wedata ike nhazi usoro nke usoro HPMC.

Fig.2 xrd nke fim HPMC n'okpuru ọdịnaya glutaldehyde dị iche iche

4.3.3 Mmetụta Glutardehyde na mmiri nke fim HPMC

Fig.4.3 mmetụta nke glutardehyde na mmiri na-esochi fim hpmc

Site na ọgụgụ 43 mmetụta nke mgbakwunye glutaldehyde dị iche iche na mmiri na-eme ihe nkiri HPMC, enwere ike ịhụ ya na mmụba nke usoro ihe nkiri glutaldehyde, mmiri nke fim HPMC dị ogologo. Ihe mmeghachi omume na-edozi ahụ na-eme na Glutardeldehyde, nke na-ebute mbelata nke ihe nkiri HPMC, si otú a na-agbadata mmiri na-eme ka mmiri si na HPMC.

4.3.4 mmetụta nke glutalaldehyde na akụrụngwa nke fim HPMC

Fig.4.4 Mmetụta nke glutardehyde na ike tensile na-agbaji nke oge ị fim hpmc

Iji nyochaa mmetụta nke glutaldehyde na akụrụngwa nke fim HPMC, ike Tencle na oge ezumike na ezumike nke fim ndị ahụ agbanweela. Dịka ọmụmaatụ, 4.4 bụ eserese nke glutaldehyde gbakwunye na ike tens ma na-egbu egbu ihe nkiri ahụ. Site na mmụba nke mgbakwunye glutaldehyde, ike tens na oge ezumike nke ihe nkiri HPMC mere ka ọ bụrụ nke mbụ wee belata. omume nke. Kemgbe njigide nke glutalaldehyde na cellulite bụ nke cong-njikọ, mgbe ị na-etinye glutaldehyde na HPMC Mode na-enwe njikọ na-eme ka a na-eme ihe na-emeghe na HPMC. fim. Na mgbakwunye na-aga n'ihu nke glutalaldehyde, njupụta nke ijikọ ihe na-abawanye, nke na-egosi na akụrụngwa akụrụngwa nke HPMC dị mkpa na-agbada macroscopically [76]. Site na ọgụgụ 4.4, mmetụta nke glutardehyde na akụrụngwa ihe nkiri HPMC na-egosi na mgbe mgbakwunye glutaldehyde bụ ọfụma, ihe ndị na-eme ihe nkiri nke ihe nkiri HPMC dị mma.

4.3.5 Mmetụta Glutardehyde na ngwa ngwa nke fim HPMC

Ntughari ọkụ na haze bụ abụọ dị oke anya ngwa ọrụ na fim fim. Ndabere ka ukwuu, ka mma nghọta nke ihe nkiri ahụ; Ohu ahu, nke a matara dika agbụrụ, na-egosi ogo nke ihe nkiri a, ka njọ nke ihe nkiri ahụ. Ọgụgụ 4.5 bụ mmetụta na mgbakwunye mgbakwunye nke glutalaldehyde na ngwa ngwa nke fim HPMC. Enwere ike ịhụ ya site na ọnụ ọgụgụ na mmụba nke mgbakwunye glutalaldehyde, ọkụ ọkụ na-ebu ụzọ jiri nwayọ na-abawanye, mgbe ahụ na-abawanye ngwa ngwa wee belata nwayọ; haze ya buru ụzọ gbadaru ma mụbaa. Mgbe mgbakwunye nke glutardehyde bụ 0.25%, ntụgharị nke ihe nkiri HPMC ruru uru kacha 93%, na haze ruru ogo nke 13%. N'oge a, arụmọrụ anya dị mma. Ihe kpatara mmụba nke ngwa ọdịnala bụ mmeghachi omume na-ejikọ aka n'etiti molerlaldes na-eme ka ọ dị iche iche, nke na-abawanye ngwa njupụta nke fim HPMC [77-79]. Mgbe onye na-ejikọ ọnụ na-agabiga, a na-akwado saịtị ndị na-edozi ahụ, na-agbada n'etiti ụmụ irighiri ihe nke sistemụ ahụ siri ike, na Genomenon dị mfe ime. Ya mere, ngwa ngwa ihe nkiri HPMC na-ebelata [80].

Fig.4.5 mmetụta nke glutalaldehyde na ihe nkiri nke fim hpmc

Akụkụ 4.4 nke isiakwụkwọ a

Site na nyocha a dị n'elu, nkwubi okwu ndị a na-adọta:

1) Ihe onyonyo a na-ahụ maka ihe nkiri glutaldehyde-crosslinking na-egosi na ihe nkiri glutalaldehyde na HPMC ihe nkiri na-enweta mmeghachi omume na-edozi.

2) Ọ dabara adaba ịgbakwunye glutaldehyde na oke 0.25% ruo 0.44%. Mgbe mgbakwunye glutaldehyde bụ 0.25%, Njirimara ọrụ zuru oke na ngwa ọdịnala nke ihe nkiri HPMC ka mma; Mgbe ị ga-ejikọ ihe nkiri, mmiri na-agbanye mmiri mmiri nke ihe nkiri HPMC, belatara mmiri mmiri. Mgbe mgbakwunye glutardehyde bụ 0.44%, oge ngụgụ ngụgụ mmiri ruru ihe dị ka 135min.

ISI NKE 5 Ihe nkiri na-egbochi ihe nkiri ngwugwu HPMC

5.1 Okwu mmeghe

Iji gbasaa ngwa nke ihe nkiri hydylypyl methylcellose na nkwakọ ngwaahịa, a na-ejikwa usoro ihe nkiri na-emepụta ihe nkiri (na-ejikwa ihe ndị na-emepụta ihe nkiri na-eme ka ọ bụrụ akụkụ dị iche iche. Ihe nkiri Antioxidont HPMC nke mmiri na-agbanye, na-amụ ihe na-egbochi antioxidant akụrụngwa, mmiri na-agbanye mmiri, akụrụngwa arụ ọrụ na ngwa ọdịnala maka ngwa ya na sistemụ nkwakọ ngwaahịa.

5.2 Akara Akaụntụ

5.2.1 Ihe nnwale na ngwa nyocha

Tab.5.1 Ihe nlere na nkọwapụta

Akwukwo nyocha nke tab.5.2

5.2.2 Nkwadebe ụdị

Nchịkọta ihe nkiri na-egbochi mmiri na-egbochi ihe dị iche iche na-edozi ahụ, wee tinye 0%, 0.03%, 0.07%, 0.07%, 0.07%, 0.09%) nke achara abata na-ejikọ mkpụrụ osisi cellulose nke mkpụrụ osisi cellulose, ma gaa n'ihu

Ka ị gwakọtara nke ọma, ka guzoro na ụlọ okpomọkụ nke 3-5 nkeji (ihe na-eme) iji dozie ngwọta FPMC nke nwere ọtụtụ akụkụ dị iche iche nke achara antioxidants. Kpoo ya na oven na-agba agba agba agba agba agba agba agba agba agba agba agba agba agba agba agbaji na-akpọ nkụ maka emechaa iji kpochapụ ihe nkiri ahụ. A na-ezo aka na ihe nkiri Hydyploplose mmiri na-agbanye na achara antioxidant anioxidant a na-ezo aka dị ka ihe nkiri Ab / Hpmc maka mkpụmkpụ.

5.2.3 njirimara njirimara na nnwale arụmọrụ

5.2.3.1 Achịcha Accorpycopy (FT-IR) nyocha

A tụlere ụdị ihe nkiri a na-egbochi ihe nkiri HPMC nke site na iji nicolet 5700 transform inframed infromed provices na-emepụta.

5.2.3.2 Scess Agle-ray Difruction (XD) nha: otu dị ka 2.2.3.1

5.2.3.3 Mkpebi nke Njirimara Njirimara

Iji tụọ akụrụngwa nke ihe nkiri HPMC na fim a kwadebere, ejiri ihe nkiri DPMC, a na-eji usoro ihe nkiri a na-eme ihe nkiri na DPP n'efu.

Nkwadebe nke DPP Ngwọta: N'okpuru ọnọdụ Sharing, igbari 2 mg nke DPPH na 40 ml nke ettanol na-agba mbọ, na sonicate maka 5 nkeji iji mee ka ihe ngwọta. Chekwaa na friji (4 Celsius C) maka iji ya emechaa.

N'izo aka na usoro nnwale nke Zhoang yuansheng [81] bụ A0. Ntinye nke uru: Tinye 2 ml nke ngwọta Ngwọta, wee tinye 1 ml nke hpmc dị nro iji mix threctophotometer, were mmiri dị ka ihe dị mma, yana data atọ maka otu ọ bụla. DPP na-enweghị atụ na usoro mgbakọ na-egosi usoro a,

Na usoro: a bụ nnabata nke ihe nlele; A0 bụ njikwa oghere

5.2.3.4 Mkpebi mkpebi nke Njirimara Ihe: Otu Dị ka 2.2.3.2

5.2.3.5 Mkpebi nke Njirimara Njirimara

Ngwongwo ngwa ngwa bu ihe ngosi di nkpa nke ihe nkiri ngwugwu, tumadi tinyere mbugharị na haze. Ejiri transmittive na haze nke fim a na-eji Transmittance Haze. A tụgharịrị na oghere na-acha uhie uhie na ime ụlọ okpomọkụ (25 ° C na 50% Rh) na nyocha nlele na-acha ọcha na-acha ọcha.

5.2.3.6 Mkpebi nke Slublity

Bee ihe nkiri 30mm × 30mm na ọkpụrụkpụ dị ihe dị ka 45μm, tinye 100ml mmiri ruo na etiti mmiri ahụ, ma tụọ oge maka fim ahụ ga-apụ kpamkpam. Ọ bụrụ na ihe nkiri ahụ rapara na mgbidi nke beaker, ọ dị mkpa ka a tụọ ya ọzọ, a na-ewere nsonaazụ ya dị ka nkezi nke ugboro atọ, ngalaba ahụ bụ min.

5.2.4 Nhazi data

Ejiri sọftụwia na-eme nyocha ahụ wee mepụta data nnwale ahụ.

5.3 nsonaazụ na nyocha

5.3.1 FT-IR nyocha

Fig5.1 FTIR nke HPMC na AOB / HPMC fim

Na Mononic Molecules, atọm na-eto nkekọ kemịkalụ ma ọ bụ otu arụ ọrụ dị na steeti na-asọ oyi mgbe niile. Mgbe a na-agbanye molecules nke a na - agbanyeghị na ọkụ, nke agbụ ma ọ bụ nke na - arụ ọrụ na - arụ ọrụ nwere ike ịmịkọta ihe dị iche iche ma ọ bụ otu na - arụ ọrụ. Ọgụgụ 5.1 na-egosi FTIR ihe nkiri nke ihe nkiri HPMC na ihe nkiri AOB / HPMC. Site na eserese nke 5, enwere ike ịhụ ya na njiri mara ọkpụkpụ nke hydropyy na-etinye uche na 2600 ~ 3700 cm-150 ~ cm-1. Mpaghara nkwugharị ahụ siri ike na 950-1250 cm-1 bụ ọkachasị agwa nke mpaghara ọkpụkpụ coneton. A na-eme ka ihe nkiri a na-eme nke ọma 3418 cm-1 bụ nke na-agbatịkwu nke otu ohdyl, na-akpata 1 cm-1 bụ nke ịgbatị mkpọda nke ntọala [82]. Ọnụ ọgụgụ dị na 1454cm-1, 1373CM-1, 1315cm-1 na 945cm-1 na-amachibido iwu Asymmetric, na-efegharị na-emegharị ụgbọ elu nke-plane bụ nke na-eme mkpọtụ nke-elekere. A na-agbanwe HPMC na AOB. Site na mgbakwunye nke AOB, ọnọdụ nke njiri mara nke AOB / HPMC agbanweghị, na-egosi na mgbakwunye AOB ibibighị ụdị HPMC n'onwe ya. Ibelata ihe ngosi nke oh na ihe nkiri Abrob nke Ab / hpmc ihe nkiri dị nso na 3418 cm-1 na-eme ka ọ dị ike nke methyy na methylene n'ihi njikọta Hydrogene. , Enwere ike ihu ya na mgbakwunye nke AOB nwere mmetụta na njikọta hydrogen.

5.3.2 xrd nyocha

Fig.5.2 xrd nke Hpmc na AOB /

Fig.2 xrd nke HPMC na Ab / HPMC Fim

Ọ na-enyocha steeti fim ahụ site na nsí X-ray. Ọgụgụ 5.2 na-egosi usoro ihe nkiri XRC nke HPMC na ihe nkiri AAOB / HPMC. Enwere ike ịhụ ya site na ọnụ ọgụgụ ahụ HPMC Ihe nkiri nwere 2 elu dị iche iche (9.5 Celsius, 20.4 Celsius). Na mgbakwunye nke AOB, ọnụ ọgụgụ dị iche iche dị iche iche 9.5 Celsius na 20.4 Celsius nke ukwuu, na-egosi na ụmụ irighiri ihe nkiri AOB / HPMC n'usoro. Ike belarị, na-egosi na mgbakwunye nke AOB megharịrị ndochi nke molecyyli Methylcellopy, ma belata nhazi oge nke hydroxyppylthylthyl.

5.3.3 Antioxidant Njirimara

Iji nyochaa mmetụta nke mgbakwunye na usoro ihe nkiri AOB / HPMC, ihe nkiri nwere mgbakwunye dị iche iche nke Aob (0.07%, 0.09%), 0.09%) na-enyocha, n'ụzọ dị n'otu. Mmetụta nke scaveng na ọnụego ya, a na-egosi nsonaazụ ya na ọgụgụ 5.3.

Fig.5.3 Mmetụta nke fim HPMC n'okpuru AOB ọdịnaya DPP

Enwere ike ịhụ ya site na eserese 5.3 na mgbakwunye nke ab antioxidant na-eme ka ihe nkiri DPH nke dị mma, yana mmụba nke ihe nkiri a na-eme ka ọ na-agbadata. Mgbe mgbakwunye AOB bụ 0.03%, ihe nkiri AOB / HPMC nwere mmetụta kachasị mma na radicals na-eru 89.34 fim na-akwụghị ụgwọ nwere arụmọrụ mgbochi na oge a; Mgbe ọdịbendị AOB dị 0.05% na 0.07%, DPP na-enweghị atụ dị elu karịa nke ihe nkiri AOB / HPMC dị elu karịa nke a, mana ọ dị ala karịa nke ndị 0.03%; Nke a nwere ike ịbụ ọgwụ mgbochi sitere n'okike nke Abglomeration nke abglomeration nke ihe nkiri AOB na ihe nkiri AOB / HPMC. Enwere ike ịhụ ya na ihe nkiri AOB / HPMC kwadebere na nnwale ahụ nwere ezigbo anti-oxidition arụmọrụ. Mgbe mgbakwunye ego dị 0.03%, arụmọrụ ọgwụ na-enweghị atụ nke ihe nkiri AOB / HPMC bụ nke kachasị ike.

5.3.4 Mmiri Sọ Okwu

Site na ọgụgụ 5.4, mmetụta nke ngwo akwukwo na-acha uhie uhie na mmiri mmiri hydycelllilose, ọ nwere ike ịhụ na mgbakwunye aeb dị iche iche nwere mmetụta dị ukwuu na mmiri na-esochi ihe nkiri HPMC. Mgbe ị na-agbakwunye AOB, na mmụba nke ego ab, mmiri-soluble oge ihe nkiri ahụ dị mkpụmkpụ, na-egosi na mmiri mmiri nke AOB / HPMC ka mma. Nke ahụ bụ ikwu, mgbakwunye nke AOB na-eme ka mmiri Ab / hpmc na-agbanye ndọkpụ nke fim ahụ. Site na nyocha XDD nke gara aga, enwere ike ịhụ ya na ịdọrọ asịrị, a na-ebelata ihe nkiri AOB / HPMC, nke na-eme ka ọ dịkwuo mfe ịbanye na usoro ihe nkiri AOB / HPMC ka ọ dị mma ruo n'ókè ụfọdụ. Mmiri na-arahụ ihe nkiri ahụ.

Fig.5.4 Mmetụta nke aob na mmiri mmiri nke fim hpmc

5.3.5 Njirimara eji arụ ọrụ

Fig.5.5 Mmetụta AOB na Ike Tenle na-agbaji Elongation nke Ihe nkiri HPMC

Ngwa nke obere ihe nkiri na-abawanye ụba, ihe ndị na-arụ ọrụ ya nwere nnukwu mmetụta na omume ọrụ nke sistemụ membrane, nke ghọrọ nnukwu ụlọ ọrụ nyocha. Ọgụgụ 5.5 na-egosi ike tensile na oge obibi na mkpokọta fim AOB / HPMC. Enwere ike ịhụ ya site na ọnụ ọgụgụ na mgbakwunye AIB dị iche iche nwere mmetụta dị mkpa na akụrụngwa arụmọrụ nke fim. Mgbe ị na-agbakwunye AOB, na mmụba nke mgbakwunye aian, AOB / HPMC. Ike nke ihe nkiri ahụ gosipụtara na-ewu ewu, ebe obibi na ezumike gosipụtara omume mbụ na-abawanye. Mgbe ọdịdị Anob dị 0.01%, elongation na izu ike fim ahụ ruru uru dị ihe dị ka 45%. Mmetụta nke AOB na akụrụngwa nke fim HPMC doro anya. Site na nyocha nke XRD, enwere ike ịhụ na mgbakwunye nke antioxidant Anoo na-ebelata kristal nke ihe nkiri AOB / HPMC, si na -ebelata ike TSOB / HPMC. Elongation na-eme ka izu ike na-abawanye ma na-ebelata, n'ihi na AOB nwere ezigbo mmiri sollity na ndakọrịta, ma dịkwa obere molecular obere molecular. N'oge ndakọrịta na HPMC, ike mmekọrịta n'etiti molecules na-esighi ike na ihe nkiri a na-eme ka ọ dị nro. Ihe owuwu siri ike na-eme ka ihe nkiri AOB / HPMC dị nro ma na mbara ntopute na oge fim ahụ na-abawanye; Ka AOB na-aga n'ihu na-abawanye, elongation na-agbada na ihe nkiri AOB / HPMC na-agbada, na ihe nkiri a na-eme ka ọ bụrụ macromolules na-abawanye, ya mere na ịba ahụ na-eme ka a na-eme ihe nkiri Ihe nkiri na-agbada.

5.3.6 Njirimara

Fig.5.6 Mmetụta nke AOB na akụrụngwa ngwa anya nke fim HPMC

Ọgụgụ 5.6 bụ eserese na-egosi mgbanwe na transmince na haze nke fim AOB / HPMC. Enwere ike ịhụ ya site na ọnụ ọgụgụ nke na mmụba nke ego AOB kwukwara, ntụgharị nke ihe nkiri AOB / HPMC na-agbadata na haze na-abawanye. Mgbe ọdịdị Anob karịrị 0.05%, mgbanwe mgbanwe nke transmitsance ọkụ na haze nke fim AOB / HPMC adịghị nwayọ; Mgbe ọdịdị Anob karịrị 0.05%, mgbanwe mgbanwe nke transminance ọkụ na-agba ngwa ngwa. Ya mere, ego nke AOB gbakwunyere ekwesighi gafere 0.05%.

5.4 Akụkụ nke Isi a

Ibelata achara na-ejikọ (AOB) dị ka ọgwụ mgbochi na hydroxyl methylcellose (HPMC) dị ka ihe nkiri na-akpụ akpụ akpụ akpụ akpụ akpụ ma na-akpụ akpụ akpụ akpụ ma na-akpụ akpụ akpụ akpụ. Ihe nkiri AOB / HPMC nke mmiri na-agbanye na nnwale a nwere arụmọrụ Njirimara nke mgbochi. Ihe nkiri AOB / HPMC nwere 0.03% AIB nwere ọnụego ihe dị ka 89% maka radicals na-akwụghị ụgwọ, yana arụmọrụ sara mbara bụ nke kachasị mma, nke dị mma karịa nke na-enweghị ọchịchị. Ihe nkiri HPMC na 61% ka mma. A na-agbanwe mmiri mmiri nke ọma, yana akụrụngwa akụrụngwa na akụrụngwa na-agbada. Ndị na-eguzogide usoro ihe nkiri AOB / HPMC emeela ka itinye ya na nkwakọ ngwaahịa.

Isi nke Vi Mmebi

1) Site na mmụba nke usoro ihe nkiri HPMC, akụrụngwa arụ ọrụ nke ihe nkiri ahụ buru ụzọ mụbaa ma belata. Mgbe HPMC na-ahụ maka ihe nkiri na-ese ihe bụ 5%, Njirimara nke ihe nkiri HPMC ka mma, ike nke Tensile bụ 116MPA. Elongation na ezumike bụ ihe dị ka 31%; Ngwongwo ngwa ngwa na mmiri ga - agbadata.

2) Site na mmụba nke ihe nkiri ahụ, Njirimara nke ihe nkiri ndị dị na fim ahụ mụbara wee belata, akụrụngwa dị mma belata. Mgbe okpomọkụ na-etolite na-acha fim dị 50 Celsius C, ike tensile dị ihe dị ka 96MPa, na mmiri ọkụ na-agbaze ihe dị ka 55min, yabụ, okpomọkụ na-etolite fim dị mma na 50 Celsius.

3) Iji fọdụrụ ndị na-eme ihe nkiri HPMC, na mgbakwunye nke Glycer, na-egbu oge fim HPMC mere nke ukwuu, ebe ike Tenlele belatara. Mgbe ego nke Glycer kwukwara dị n'etiti 0.15% na 0.15%, mkpọda na-agbaji ihe nkiri HPMC bụ ihe dị ka 50%.

4) Site na mgbakwunye nke sorbil, elongation na izu ike fim na-abawanye mbụ wee belata. Mgbe mgbakwunye nke sorbil bụ ihe dị ka 0.15%, mbara ala na-eru 45% na ike tensile dị ihe dị ka 55MPA.

5) Ihe mgbakwunye abụọ chara rọbi abụọ, Glycel na sornol, ha abụọ belatara ngwa ngwa ihe ngosi na ngbanwe nke fim HPMC, na mbelata nke ihe nkiri HPMC, ebelata ya abụghị nke ukwuu. Tụnyere mmetụta rọba nke rọba abụọ na fim HPMC, enwere ike ịhụ ya na mmetụta rọba nke glycel dị mma karịa nke sorbol.

6) Site na ihe ngosi a na-egbochi infrarroscopy (FTIR) na nyocha nke X-ray Specialtion, njigide nke glutalaldehyde na klọọkụsịrị na mkpumkpu ahụ mgbe ị ga-amụ ihe. Site na mgbakwunye nke ndị na-ejikọ ọnụ na-ejide ya glutaldehyde, ike tensile na oge ezumike nke FPMC fim ahụ kwadebere na mgbe ahụ. Mgbe mgbakwunye nke glutardehyde bụ 0.25%, Njirimara nke ihe nkiri HPMC dị mma; Mgbe ịgafesịrị, oge ị ga-enwe ogologo oge, na mmiri-solub na-ebelata. Mgbe mgbakwunye glutardehyde bụ 0.44%, oge ịkwado mmiri ruru ihe dị ka 135min.

7) Dinggbakwunye ọgwụ mgbochi kwesịrị ekwesị na usoro ihe nkiri HPMC, nke a kwadebere mmiri ab / hpmc mmiri na-agbanye mmiri nwere akụrụngwa akụrụngwa nke mgbochi. Ihe nkiri AOB / HPMC nwere 0.03% AIB gbakwunyere 0.03% ka ọ bụrụ radicals na-enweghị ike, nke bụ 61% dị elu karịa nke fim HPMC na-enweghị AOBC. A na-agbanwe mmiri mmiri nke ọma, yana akụrụngwa akụrụngwa na akụrụngwa na-agbada. Mgbe mgbakwunye 0.03%, mmetụta nke ọgwụ nje dị mma, na mmezi nke ihe nkiri AOB / HPMC na-agbasa ngwa nke ihe nkiri ihe nkiri a na nkwakọ ngwaahịa.

Oge post: Sepp-29-2022

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Nkwadebe na akụrụngwa nke hydroxypypylthylcelllose