HPMC (hydroxylthylthylthylthylcelllose) bụ ogige nke polymer na-ejikarị ọgwụ, ejikarị ọgwụ, nri, ihe ịchọ mma, na ụlọ ọrụ mkpuchi. A na-emetụta arụmọrụ ya site na ọtụtụ ihe n'etiti ọnọdụ okpomọkụ nwere ihe kachasị dị mkpa na viscosity nke viscosity nke HPMC Ngwọta.
1. Njirimara njirimara nke HPMC
HPMC bụ ihe polymer na-enwetara site na ngbanwe kemịkalụ nke osisi osisi sellose. Ọ nwere ezigbo mmiri sogbality, akụrụngwa na-akpụ akpụ ihe nkiri, oke na nkwụsi ike. N'ihi na ihe okike ya nwere hydrophilic òtù dị ka Hydroxy na Methyl, HPMC nwere ike ịmalite usoro viscs ihe nlere na mmiri. Vita ya nwere ike isikọpụta ihe dịka ịta ahụhụ, ogo molecular, okpomọkụ, na uru nke ihe ngwọta.
2. Mmetụta nke okpomoku na viscosity nke HPMC Ngwọta
Mmụba na ọnọdụ okpomọkụ na-eduga na mbelata na viscosity
Nleta viscitty HPMC Nellzọ na-agbadata na oke okpomọkụ, nke yiri Njirimara nke ọtụtụ ngwọta polymer. Mgbe ọnọdụ okpomọkụ na-acha, na-agagharị nke molecules mmiri na ihe ngwọta dị n'etiti molecules (dịka njikọta hydrogen) na-eme ka mbelata nke mgbanwe HPMC Kpamkpam, mmụba nke okpomọkụ nke ji nwayọọ nwayọọ na-ebibi njikọta nke anụ ahụ na hydrogen bong dị n'etiti, na-ekwe ka akwara dịkwuo elu, nke na-ebutekwa nliology mekwuru ya ma belata vissiosis.
Mmetụta nke okpomọkụ na molecular ngagharị
Ọdịvancosity nke HPMC Ngwọta abụghị naanị metụtara ya na oke molecular na ịta ahụhụ, mana ọ bụ njikọ chiri anya na ngagharị nke eriri ahụ. Mmụba na ọnọdụ okpomọkụ na-abawanye ngagharị mmiri nke molecules na ihe ngwọta, yana ọrụ nke eriri HPMC na-abawanye. Dị ka ọnọdụ okpomọkụ na-abawanye, mgbanwe nke eriri HPMC na-abawanye, ma nwee ike ịbawanye okirikiri nke ihe ngwọta ahụ, gosipụtara dị ka ibe ya na viscosity.
Nyocha usoro nke usoro ihe na-emetụta
Mmekọrịta dị n'etiti viscosity na okpomoku nke Ngwọta HPMC nwere ike ịkọwa site na ndọchi anya ardenius. Itinye ihe na-egosi na enwere ụfọdụ mmekọrịta dị n'etiti viscosity nke ihe ngwọta na okpomọkụ ahụ. Kpamkpam, viscosity (η) nke ihe ngwọta a nwere ike ịkọwa dị ka:
= η0 emeghe (Rtea)
N'etiti ha, η_0 bụ oge niile, e_a bụ ike mgbali, r bụ gas mgbe niile, ma t ka okpomọkụ. Na oke okpomọkụ, ike ịgbalite ahụ nwere mmetụta dị ukwuu, na-eme ka viscosity nke ihe ngwọta iji dobe nke ọma na mmụba na ụba.
Nkwụsi ike nke ngwọta HPMC
Ọ bụ ezie na viscosity nke HPMC na-agbadata na mbara igwe, HPMC Ngwọta nwere ezigbo nkwụsi ike n'ime ụfọdụ ọnọdụ okpomọkụ. Na ultra-elu okpomọkụ, agbụ abụọ nke Hpmc nwere ike ịbelata, na-ebute mbelata nke akwara ya, nke na-eme ka mbenatọ dị nkọ na viscosity. Ya mere, na ngwa bara uru, a ga-ezere idozi hpmc site na ikpughere gburugburu okpomọkụ karịrị ala na-akwụsi ike.
3.
Ụlọ ọrụ ọgwụ
N'ime ụlọ ọrụ ọgwụ, a na-ejikarị HPMC na-anọkarị maka ọgwụ maka ọgwụ, ihe maka capsule shells, na ihe dị mfe maka nkwadebe ndị ọzọ siri ike. Mmetụta nke okpomọkụ na viscosity ya metụtara ogo na usoro nkwadebe nke nkwadebe. Oke okpomọkụ ga-ebute obere ọhụụ ngwọta, na-emetụta ọnụego ngwọta na mmetụta nchịkwa nke ọgwụ, yabụ ọ dị mkpa iji rụọ ọrụ n'ime ọnọdụ okpomọkụ kwesịrị ekwesị.
Ụlọ ọrụ nri
N'ime ụlọ ọrụ nri, a na-eji HPMC mee ihe dị ka nke na-eto eto na emunsufier. N'oge ịhazi nri, ntụgharị okpomọkụ nwere ike imetụta nha nke HPMC Ngwọta, si otú ahụ na-emetụta uto na udidi nke ngwaahịa ahụ. Ya mere, manyere njirimara viscosit nke HPMC Ngwọta na oge dị iche iche ga - enyere aka ịchịkwa usoro nri nri ma hụ na nkwụsi ike na uto nke ngwaahịa ikpeazụ.
Ụlọ ọrụ na-ewu ụlọ
N'ime ụlọ na mkpuchi, isi ọrụ HPMC dị ka ihe na-ejigide na mmiri. Ka ọnọdụ okpomọkụ na-agbanwe, mgbanwe viscitseth nke HPMC ga-emetụta ọnya mmiri, adhesion na ịrụ ọrụ nke ihe ma ọ bụ mkpuchi. Ya mere, na ngwa bara uru, ọ dị mkpa idozi ego HPMC dị ka ọnọdụ okpomọkụ iji hụ na ọ ga-enwe ọganihu dị mma.
Ụlọ ọrụ ịchọ mma
Na ịchọ mma, a na-ejikarị HPMC na-ejikarị ya na usoro nke ngwaahịa dị ka gels na emulsions. Mmetụta nke okpomọkụ na viscosity nke HPMC nwere ike imetụta mgbasa ozi, nkwụsi ike na ọdịdị ederede nke ngwaahịa ahụ. N'oge dị iche iche, mgbanwe ọhụụ nke ịchọ mma nwere ike imetụta ahụmịhe onye ahịa ahụ, yabụ achọrọ njikwa ọnọdụ okpomọkụ n'oge usoro mmepụta.
Mmetụta nke okpomoku na viscosity nke hpmc ngwọta bụ ihe dị mgbagwoju anya na usoro kemịkalụ dị ka mgbanwe nke eriri dị iche iche na mgbanwe na-agbanwe agbanwe. N'ikwu na, mmụba nke okpomọkụ ga-eduga ngbanwe nke viscosis nke HPMC Ngwọta, dị ka usoro ọnọdụ, itinye uche, na ịdị arọ molecular arọ nke hpmc. Site na ịmụta mmekọrịta dị n'etiti viscosity na ọnọdụ okpomọkụ nke ọrụ sayensị maka itinye sayensị na-arụ ọrụ nke ọrụ dị iche iche, na-ebulite ogo ngwaahịa.
Oge post: Feb-15-2025