Ọgwụ ọgwụ na-emepụta ọgwụ bụ ihe na-eme ka ọ bụrụ nke na-emepụta ihe na mmepụta ọgwụ, ma dịkwa mkpa nke nkwadebe ọgwụ. Mkpụrụ osisi polymese dị ka ihe sitere na polymes polymes, nwere njiri cellulose, ethylypyl cellulose, ethylyyl cellose, ethdy cellulose, celdyprosethy cellulose, cellylose ellicurice uru ọgwụ. Ugbu a, ọtụtụ ngwaahịa ụlọ ọrụ nke ụlọ ọrụ na-enweghị atụ na njedebe nke ụlọ ọrụ, ọnụahịa ahụ adịghị elu, ụlọ ọrụ dị mkpa ngwa ngwa, meziwanye ngwa ngwaahịa.
Ahịa ọgwụ na-ezighi ezi nwere ike buru ibu
Ọgwụ gbasara ọgwụ na-arụ ọrụ dị mkpa na mmepe na mmepụta nke nkwadebe ọgwụ. Dịka ọmụmaatụ, na njikere ma levether, cellulose eutymer na ihe ndị ọzọ dị ka akwụkwọ na-emepụta ọgwụ, na-akwadebe ọgwụ a na-akwadebe na njikere a na-akwadebe na-akwado. Na usoro ihe a, a na-ejikarị polmers ndị ọzọ dị ka onye na-ebu ọgwụ ike iji chịkwaa ya na ahụ mmadụ, ya bụ, ha chọrọ ka ahapụ ha na otu oge iji nweta ebumnuche nke ọgwụgwọ dị irè.
Dabere na ọnụ ọgụgụ nke nyocha Zhiyan na Ngalaba nyocha, ma e jiri ya bụrụ ụdị dị iche iche nke United States, ụdị ka obere, ụdị ọgwụ ọgwụ China ka nwere ike buru ibu. A ghọtara na ọgwụ ọgwụ kachasị elu na ahịa China nwere ọgwụ na-egbu egbu, pvdypyl na cellulose (hpmc), microcrystalline cellulose, HPC, lactose.
Isiiụdị nkecellugul ethern'imeỌrịa ọgwụ
Oke seut bụ alkali cellulose na onye na-eme ihe na-enye ihe dị n'okpuru ọnọdụ mmeghachi omume iji mepụta usoro nke mkpụrụ osisi celdrolose, bụ nke ngwaahịa a dochie ya kpamkpam. A na-eji Ewet na-ejikarị mmanụ, ihe eji eme ihe, nri, ọgwụ, ọgwụ, na-eto eto n'ubi, yana ọnụahịa dị elu nke ụlọ ọrụ, yana ọnụahịa dị elu. N'ihi nkwanye ugwu dị mma, mmepụta nke ọkwa ọgwụ na-enweghị isi, enwere ike ikwu na ogo nke ngwaahịa ọkwa ọgwụ nwere ike ịnọchite anya ike ọrụ nke cellulose nke ụlọ ọrụ cellulu. A na-ejikarị ya dị ka ihe mgbochi, ọkpụkpụ ọkpụkpọ na viocosifier iji tinye, ihe ndị na-eme ihe nkiri microtoped ihe nkiri, na-ejikwa ihe nkiri na-emegharị emegharị ọgwụ.
Sodium carloxyyythythythythyl
A na-eji akwa nke sodium nke sodinosethythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythy bụ mkpụrụ kachasị ukwuu na usoro nke alkali, osisi chlorocetic ekikere ether. CMC-na bụ ụdị ọgwụ na-ejikarị eme ihe na-ejikarị, nke a na-ejikarị ngwa ọrụ maka nkwadebe siri ike na viscus, yana matrik na ihe nkiri mepụtara ihe. Na njikere mwepụ a na-akwado ya, a na-ejikarị ya mee ihe nkiri maka ọgwụ na-adịghị alada na mbadamba okwu maka ịhapụ ngwa ngwa.
In addition to sodium carboxymethyl cellulose as pharmaceutical excipients, crosslinked sodium carboxymethyl cellulose can also be used as pharmaceutical excipients. Counium counduxylythythythythythythylythythylythylythylythylythylythylythyth celluble ihe dị ọcha nke celloxyl cellultio na ụfọdụ okpomọkụ (40 ~ 80 ℃) n'okpuru omume nke inorganic acid. Onye na-achọsi ike nwere ike ịbụ proslene glycol, succinic Arehydride, Anhydride na Adipic Arepic. A na-eji sodium coulloxyyythylythylylythyl na-aga n'ihu na mbadamba ụrọ, capsules na granales na ịkwadebe nke ịkatọ, na-enwe ike nghọtahie, ike ya dị mma. Studies egosila na ogo ọzịza nke calloxythythylythylythylythyl elu karịa nke sodium cellobose na cellratedsstaltine cellose na ndị ọzọ na-adịghị ala ala.
Methyl celluse
Methy Cellulose (Mc) bụ otu cellonic cellulose ether nke mere na owu na osisi site na alkalization, Chloromethanification na usoro ndị ọzọ. Methyl cellulose nwere ezigbo mmiri solubality ma kwụsie ike na plọ 8,0 ~ 13.0. A na-eji ya n'ọtụtụ mbadamba ọgwụ, supblesculess, injectioncular ntụtụ, nkwado onu, mbadamba onu, mbadamba onu, mbadamba onu na nkwadebe obodo. Na mgbakwunye, enwere ike iji Mc dị ka usoro gel a na-ejikọ ya na-akwado, ihe eji eme ihe na-egbochi ihe nkiri, na-akwadebe ihe nkiri a na-ahụ maka ihe nkiri ọgwụ, na-akwadoro ihe nkiri na-eme ọgwụ, wdg.
Hydroxypylthyl methyl cellulose
Hydroxypyl Methyl Cellulose (HPMC) bụ nondilose agwakọta ether ether nke emere site na ngụgụ, propyle oxide na chloromethaina kan na chloromethai. Ọ bụ pumpless, keenweghiuto na anaghị egbu egbu, soluble na mmiri oyi na gelatinous na mmiri ọkụ. Hydroxypylthylthyl methyl cellulose bụ mkpụrụ ụlọ, onunu ogwu na ogo cellulose agwakọta, bụkwa otu n'ime nnukwu ọgwụ na mba ọzọ, dị ka ọgwụ na-esite na akụkọ ntolite 50. Ka ọ dị ugbu a, a na-egosi ngwa HPMC na akụkụ ise ndị a:
Otu dị ka ihe mgbochi na ịchekwa ihe. HPMC dị ka ihe mgbochi nwere ike ime ka ọgwụ dị mfe mmiri, mmiri ya nwere ike ịgbasa ọtụtụ narị ugboro, ya mere ọ nwere ike ime ka mgbasa na mbadamba. HPMC nwere viscosity dị ike, maka udidi nke crisp ma ọ bụ akụrụngwa siri ike nwere ike ịkwalite urughuru viscssity, ka mmaliputa ya. Enwere ike iji viscosity dị ala na-egbukepụ dị ka ihe mgbochi na ịpụpụ ihe, viscosity dị ka ihe mgbochi.
Nke abụọ bụ ihe na-adịghị nwayọ ma na-achịkwa maka nkwadebe onu. HPMC bụ ihe a na-eji eme ihe na-ejikarị njikere na-akwado ya. Enwere ike iji HPMC nke dị ala (5 ~ 50MPave) enwere ike iji ya dị ka onye na-ahụ maka mgbaaka, ebe HPMC nke nwere oghere nke ngwa ahịa na-eme ka ọ bụrụ ihe mkpuchi mbadamba mbadamba. Enwere ike ịgbasa hpmc ahụ na mmiri na-eme ka ọ dị mma, na-enwekarị ihe dị mma na-ejikọ ya na ihe eji eme ya, ma jiri ya mee ihe mkpuchi mmiri Ndị na-ekwu okwu.
Nke ato, dika ihe nkiri a na-emechi - imeputa ihe. HPMC nwere ezigbo ihe nkiri, o doro anya, adịghị mfe, mmepụta adịghị mma, na-egbochi ntụpọ ihe nkiri. HPMC nwere nkọwapụta dị iche iche dị iche iche, dị ka nhọrọ dị iche iche, mkpuchi dị mma karịa ihe ndị ọzọ, ọ na-ejikarị 2% ~ 10%.
Nke anọ bụ dịka capsule capsule. N'afọ ndị na-adịbeghị anya, ya na ntiwapụ nke anụmanụ na-egbu egbu n'oge na-adịbeghị anya, ma e jiri ya tụnyere okpu Gelatin, ahịhịa na-akụta ọhụụ nke ọgwụ na nri. Pfizer enwewo hpmc nke ọma site na osisi sitere n'okike ma kwadebere VCACTM Pulsules. E jiri ya tụnyere ọdịnala gelatin ọdịnala, osisi nkụnye nwere uru dị ukwuu nke ime mgbanwe, enweghị ihe ọghọm na-edozi ahụ na nkwụsi ike. Ọnụego ntọhapụ ọgwụ dịtụ oke, ndịrịta iche dị obere, ha anaghị etinye aka na ahụ mmadụ, a ga-ewepụkwa ya n'ahụ. N'ihe banyere nchekwa nchekwa, site na ọnụ ọgụgụ buru ibu nke nnwale, capsules na-agaghị emebi emebi n'okpuru ọnọdụ iru mmiri, na indexes nke osisi capsulas n'okpuru ọnọdụ nchekwa. Site na nghọta ndị mmadụ banyere capsules nke osisi, yana mgbanwe nke esemokwu ọgwụ ọha n'ụlọ na mba ofesi, ihe a chọrọ iji kụọ ngwa ngwa.
Ise dị ka onye nnọchi anya. A na-ejikarị nkwadebe kwụsịtụrụ na ụdị usoro onunu ogwu, nke bụ usoro mgbasa ozi siri ike nke ọgwụ mgbochi na-akụgharị na mgbasa ozi mmiri. Nkwụsi ike nke usoro ahụ na-ekpebi ogo nke ịkwadebe mmiri. Ngwọta HPMC nwere ike belata nsogbu siri ike nke mmiri siri ike, belata usoro mgbasa ozi siri ike, nke mere na usoro mgbasa ozi na-enweghị ike na-akwụsi ike, bụ onye nnọchianya dị mma. A na-eji HPMC mee ihe dị ka nke na-agbada anya, na ọdịnaya ahụ bụ 0.45% ~ 1.0%.
Hydroxypropyrl cellulose
Hydroxypropy Cellulose (HPC) bụ otu cellonic cellulose nke ether mere site na owu na osisi site na alkalization, proplene oxigification na usoro ndị ọzọ. HPC na-abụkarị nke mmiri dị n'okpuru 40 ℃ na ọnụ ọgụgụ buru ibu nke sọsọsụ polar. Njirimara ya metụtara ọdịnaya nke hydropyyl na ogo polymerization. HPC nwere ike dakọtara na ọgwụ dị iche iche ma nwee ezigbo inertia.
Obere Celdroposed Celdropose (L - HPC) ọkachasị maka mbadamba mbadamba, atụmatụ ya dị mfe, na-eme ka usoro ihe nkiri dị mfe, ma melite mmetụta ị na-eme.
Enwere ike iji Celdropose (H-HPC) mee ihe dị ka ihe mkpuchi maka mbadamba, granule na ezigbo Groule na Regional. H-HPC enwewo ihe nkiri dị mma, ihe nkiri ahụ nwetara bụ ihe siri ike ma sie ike ma e jiri ya tụnyere plastizer. Site na ịgwakọta ndị ọzọ na-egbochi mmiri, enwere ike ịbawanye arụmọrụ ihe nkiri, a na-ejikarị ya dị ka ihe nkiri mkpuchi maka mbadamba. Enwere ike iji H-HPC mee ihe dị ka ihe mkpuchi iji dozie mbadamba ihe, na-elekọta pellets na mbadamba ihu abụọ.
Hydroxyethyth Celluse
Hydroxyethythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythythyth bụ otu cellonic sel cellulose nke emere site na owu na osisi site na alkalization, ethlene oxigification na usoro ndị ọzọ. A na-ejikarị HEC dị ka onye na-echebe, ihe nrapado, na-addesive, dispersant, stofter, onye na-eme ihe nkiri, ihe nkiri na-eme ka ọ bụrụ ihe nkiri na ahụike. Enwere ike iji ya na emulsions ọgwụ mpaghara, anya mmiri, mmiri mmiri, mbadamba siri ike, capsules na usoro onunu ogwu. Hydroxyethythythythythythythythythythythythythythythythythythythsose etinyela na United States Phaultopoeia / United States recopopoea.
Ethyl cellulose
Ethyl Cellulose (ec) bụ otu n'ime mmiri mmiri na-ejikarị mkpụrụ osisi cellivase. EC bụ ihe na-adịghị mma ma sie ike, na-enweghị ntụpọ na mmiri, acid ma ọ bụ azịza alkali, soluble na ethanol, methanol na ndị ọzọ sonvic. Sinvents nkịtị bụ toluene / ethanol mix nke 4/1 site na ibu. EC nwere ọtụtụ ndị na-eji ọgwụ na-achịkwa ọgwụ, ejikarị ndị na-ebu ihe nkiri na-achịkwa, nke a na-eji eme ihe nkiri, nke a na-eji eme ihe nkiri, na-ejikwa ọgwụ micro nke ọma Nkwadebe ihe eji eme ihe nke micro capsule; Enwere ike iji ya rụọ ọrụ nke ọma dị ka ihe na-ebu iji kwadebe mgbakwunye siri ike. A na-ejikarị ya na teknụzụ ọgwụ dị ka ihe nkiri na-eme ihe na mkpuchi nchebe, yana ihe mkpuchi na fild. Dị ka mkpuchi nke mbadamba, ọ nwere ike belata ezi uche nke mbadamba ụrọ na igbochi ọgwụ ndị a na-emetụ ya n'obi na violoration. Ọ nwekwara ike mepụta polymen adhesive ma na-eme ka polymen nwere microtoles, ka enwere ike ịhapụ ọgwụ ọgwụ ahụ mgbe niile.
Anyị ga-ekpochapụ etiti - na ngwa dị ala ma mee ngwangwa mgbanwe na ịkwalite
Cellulose, methyyythythythythythythythythythythythyyyythyyymythythythyyyythythythyym cellulose, hydroxyl Methyl Cellulse na-ejikwa ihe, na-ejikwa ihe nkiri na-achịkwa, na-agbachitere ihe nkiri, ihe nkiri Capsule Capsule na Enyemaka Enyemaka Ọgwụ ọjọọ. Na-ele ụwa anya, ọtụtụ ụlọ ọrụ mba ọzọ (Japan Doo, United States Dew Grow Walf na Ashland n'ọdịnihu, ma ọ bụ nwekwuo imepụta ntinye akwụkwọ na mpaghara a. Iwe mara ọkwa na ọ ga-elekwasị anya na usoro iwu, ihe ndị na-eme ka ahịa ọgwụ ndị China, yana mbọ ọ na-eme iji webata nyocha itinye akwụkwọ na ahịa. Ngalaba cellulose na agba agbagowo na-eme ka mmadụ nwee njikọ zuru ụwa ọnụ maka usoro a na-achịkwa, 15200 ụlọ ọrụ na-arụ ọrụ ndị ahịa na-enyefe ndị ahịa ihe dị ka mba 160. Ashland nwere ụlọ ọrụ na-emepụta ihe na Beijing, Tianjin, Shanghai, na-agbanwe, Kungmen, tinyekwara ego na ụlọ ọrụ nyocha teknụzụ atọ na Shanghai na Nanj.
Dabere na weebụsaịtị nke ngwakọta China Counsose ether, na 2017, mmepụta ụlọ nke cellulose ether 373,000 tọn, olu ahịa bụ 36,000. N'afọ 2017, olu ire ere Ionic bụ 234,000, na 18.61% afọ n'afọ, na nke na-abụghị nke Ion-ion-ion, na 8.2% n'afọ. Ngwaahịa na-abụghị nke Ionic na hpmc (ihe eji eme ihe), hpmc (ọgwụ), hcmc (nri), MC, MC, MCC, n 'imepụta na ịre ahịa na ịba ụba. Ihe karịrị afọ iri, mmepụta abụrụla nke mbụ, arụpụtala ọtụtụ ngwaahịa nke ụlọ ọrụ, ọnụahịa ahụ adịghị elu.
Ebugharị dị iche iche nke Ether n'ụlọ na mba ọzọ, ọkachasị n'oge dị oke mkpa nke ịghazi ngwaahịa, mee ka ọrụ dị elu karịa na ụlọ ọrụ ụlọ ọrụ, na-achọpụta nnukwu ọrụ na mmepe mmepe.
Oge post: Jan-27-2022